Gold M D, Blum A, Ames B N
Science. 1978 May 19;200(4343):785-7. doi: 10.1126/science.347576.
A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the Salmonella-mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant, 1,3-dichloro-2-propanone, is a potent mutagen in the absence of such activation. A flame retardant with similar structure, tris-(2,3-dibromopropyl)phosphate (tris-BP), was shown previously to be a mutagen, to cause sterility in animals, to be a carcinogen, and to be absorbed through human skin. These and other flame retardants have characteristic nuclear magnetic resonance spectra that can be used to determine which flame retardant is present in commercially purchased sleepwear. Sleepwear treated with tris-BP, Fyrol FR2, and other chemical additives was being sold in late 1977.
一种用于儿童睡衣的阻燃剂，磷酸三（1,3 - 二氯 - 2 - 丙基）酯（Fyrol FR2）在经小鼠或大鼠肝脏匀浆激活后，在沙门氏菌 - 哺乳动物组织匀浆试验中是一种诱变剂。预期的酶促水解产物1,3 - 二氯 - 2 - 丙醇在经肝脏匀浆激活后同样是一种诱变剂。该阻燃剂的一种推测代谢物1,3 - 二氯 - 2 - 丙酮在无此类激活的情况下是一种强效诱变剂。一种结构相似的阻燃剂，磷酸三（2,3 - 二溴丙基）酯（tris - BP），先前已被证明是一种诱变剂，可导致动物不育，是一种致癌物，并可通过人体皮肤吸收。这些以及其他阻燃剂具有特征性的核磁共振光谱，可用于确定市售睡衣中存在哪种阻燃剂。1977年末，用tris - BP、Fyrol FR2和其他化学添加剂处理过的睡衣仍在销售。
