Orlic D, Lev R
Lab Invest. 1977 Dec;37(6):554-61.
Human small intestine was obtained from fetuses at 8 to 20 weeks of gestation. The tissues were examined by electron microscopy. Lymphocytes were present as isolated cells in the mucosal mesenchyme as early as the 8th week of intrauterine life and were found, in increasing numbers, in the epithelium of specimens obtained from 11- to 20-week-old fetuses. All intraepithelial lymphocytes were located in the lateral spaces between contiguous columnar cells. Some displayed cytoplasmic pseudopods and were thought to migrate within the extracellular spaces of the epithelial layer. Surface invaginations and cytoplasmic vesicles in fetal lymphocytes suggested that these cells were capable of pinocytotic activity. The possibile origin and function of lymphocytes in fetal small intestine are discussed.
从妊娠8至20周的胎儿获取人小肠。组织通过电子显微镜检查。早在子宫内生活的第8周，淋巴细胞就作为孤立细胞存在于黏膜间充质中，并且在从11至20周龄胎儿获取的标本的上皮中发现数量不断增加。所有上皮内淋巴细胞都位于相邻柱状细胞之间的侧向间隙中。一些显示出细胞质伪足，被认为在上皮层的细胞外空间内迁移。胎儿淋巴细胞中的表面内陷和细胞质小泡表明这些细胞具有胞饮活性。讨论了胎儿小肠中淋巴细胞的可能起源和功能。
