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人类胎儿回肠中的T细胞亚类。

T cell subclasses in fetal human ileum.

作者信息

Spencer J, Dillon S B, Isaacson P G, MacDonald T T

出版信息

Clin Exp Immunol. 1986 Sep;65(3):553-8.

PMID:3536221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542495/
Abstract

Lymphocytes within fetal human ileum were studied by immunocytochemistry to determine the appearance of T cells in human small intestine and the role of enteric antigen in the accumulation of cells of the suppressor/cytotoxic phenotype in the gut epithelium. In fetal human gut epithelium, cells bearing the pan T cell marker UCHT1 (CD3) were present in all of the specimens studied (11-19 weeks gestation). Of these, UCHT4+ (CD8, suppressor/cytotoxic phenotype) predominated over the leu3a+ (CD4, helper/inducer phenotype), although the differences were not as marked as in postnatal gut. UCHT1+ cells were also present in the lamina propria, frequently as small aggregates beneath the epithelium.

摘要

通过免疫细胞化学方法研究了胎儿人回肠中的淋巴细胞，以确定T细胞在人小肠中的出现情况，以及肠道抗原在肠道上皮中抑制/细胞毒性表型细胞积累中的作用。在胎儿人肠道上皮中，所有研究标本（妊娠11 - 19周）中均存在携带泛T细胞标志物UCHT1（CD3）的细胞。其中，UCHT4 +（CD8，抑制/细胞毒性表型）细胞比leu3a +（CD4，辅助/诱导表型）细胞占优势，尽管差异不如出生后肠道中明显。UCHT1 +细胞也存在于固有层中，常在上皮下方形成小聚集体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ee/1542495/9de7569c842b/clinexpimmunol00120-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ee/1542495/fd5705f59b7e/clinexpimmunol00120-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ee/1542495/9de7569c842b/clinexpimmunol00120-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ee/1542495/fd5705f59b7e/clinexpimmunol00120-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ee/1542495/9de7569c842b/clinexpimmunol00120-0086-a.jpg

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本文引用的文献

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Gut. 1965 Jun;6(3):225-9. doi: 10.1136/gut.6.3.225.
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Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies.大鼠小肠上皮内、固有层和派尔集合淋巴结淋巴细胞：根据免疫球蛋白标记物和单克隆抗体受体进行分离与特性鉴定
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Lyt phenotype and lectin binding properties of mouse lymphocytes which enter lymph nodes.
母体肠道微生物组调节后代对 RSV 感染的免疫。
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Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.发育中的人类皮肤含有表现出记忆特征的淋巴细胞。
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Mechanisms of Fetal T Cell Tolerance and Immune Regulation.胎儿T细胞耐受性与免疫调节机制。
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Viable bacterial colonization is highly limited in the human intestine in utero.在子宫内，人类肠道中能够存活的细菌定植受到极大限制。
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Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort.日本孕妇的母体微生物群与婴儿早期皮炎累积患病率的关联：千叶母婴健康出生队列研究的一项初步研究
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CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.CD161 有助于 IFNγ 产生的 PLZF+T 细胞的产前免疫抑制。
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进入淋巴结的小鼠淋巴细胞的Lyt表型和凝集素结合特性。
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