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皮质醇对成年和胎鼠血细胞比容值及血清电解质的影响。

The effect of cortisol on the haematocrit values and serum electrolytes of the adult and foetal rat.

作者信息

Seller M J

出版信息

J Physiol. 1966 Jun;184(3):657-62. doi: 10.1113/jphysiol.1966.sp007938.

DOI:10.1113/jphysiol.1966.sp007938
PMID:6007110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1357606/
Abstract
  1. The serum sodium, potassium and chloride levels of the non-pregnant rat, pregnant rat and foetus were estimated under normal circumstances and following the administration of 3 mg/kg cortisol to the non-pregnant and pregnant rat.2. Normally, the electrolytes and haematocrit value of the non-pregnant rat and the electrolytes of the foetus were higher than those occurring in the pregnant rat.3. After treatment with cortisol, the sodium, potassium and chloride content of the serum, and the haematocrit value of the non-pregnant rat dropped significantly. There was no change in these values in the pregnant animals, but the foetus showed a significant decrease in sodium, potassium and chloride levels after maternal treatment.
摘要

  1. 在正常情况下以及对未怀孕大鼠和怀孕大鼠给予3mg/kg皮质醇后，测定未怀孕大鼠、怀孕大鼠和胎儿的血清钠、钾和氯水平。

  2. 正常情况下，未怀孕大鼠的电解质和血细胞比容值以及胎儿的电解质高于怀孕大鼠。

  3. 用皮质醇治疗后，未怀孕大鼠血清中的钠、钾和氯含量以及血细胞比容值显著下降。怀孕动物的这些值没有变化，但母体治疗后胎儿的钠、钾和氯水平显著降低。

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J Physiol. 1966 Jun;184(3):657-62. doi: 10.1113/jphysiol.1966.sp007938.
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本文引用的文献

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Some effects of high and low sodium intakes during pregnancy in the rat. II. Electrolyte concentrations of maternal plasma, muscle, bone and brain and of placenta, amniotic fluid, fetal plasma and total fetus in normal pregnancy.孕期大鼠高钠和低钠摄入的某些影响。II. 正常孕期母体血浆、肌肉、骨骼和大脑以及胎盘、羊水、胎儿血浆和全胎儿的电解质浓度
J Nutr. 1962 May;77(1):43-51. doi: 10.1093/jn/77.1.43.
2
The pituitary and adrenal cortex in general medicine.普通医学中的垂体与肾上腺皮质。
Br Med J. 1960 Aug 20;2(5198):553-8. doi: 10.1136/bmj.2.5198.553.
3
The effect of maternal overhydration on the rat foetus.母体水分过多对大鼠胎儿的影响。
Q J Exp Physiol Cogn Med Sci. 1963 Jul;48:292-7. doi: 10.1113/expphysiol.1963.sp001667.
4
Influence of cortisol, aldosterone and 2-methyl-1,2-di-3'-pyridylpropan-1-one on cerebral water content.
J Endocrinol. 1962 Sep;25:115-8. doi: 10.1677/joe.0.0250115.
5
The hydrocortisone production in late pregnancy.妊娠晚期氢化可的松的产生
J Obstet Gynaecol Br Emp. 1959 Jun;66:404-8. doi: 10.1111/j.1471-0528.1959.tb02048.x.
6
Hydrocortisone in foetal plasma following intravenous administration of hydrocortisone to the mother. I. With special reference to the binding of hydrocortisone by plasma proteins.母体静脉注射氢化可的松后胎儿血浆中的氢化可的松。I. 特别提及氢化可的松与血浆蛋白的结合。
Acta Obstet Gynecol Scand. 1961;40:174-80. doi: 10.3109/00016346109157857.
7
Significance of the concentration of nonprotein-bound plasma cortisol in normal subjects, Cushing's syndrome, pregnancy, and during estrogen therapy.
J Clin Endocrinol Metab. 1960 Nov;20:1484-92. doi: 10.1210/jcem-20-11-1484.
8
Binding of corticosteroids by plasma proteins. VI. The binding of cortisol and aldosterone by corticosteroid-binding globulin and by the estrogen-induced binding system of plasma.血浆蛋白与皮质类固醇的结合。VI. 皮质醇和醛固酮与皮质类固醇结合球蛋白以及血浆雌激素诱导结合系统的结合
J Clin Endocrinol Metab. 1961 Jan;21:53-61. doi: 10.1210/jcem-21-1-53.
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Transcortin: a corticosteroid-binding protein of plasma. II. Levels in various conditions and the effects of estrogens.皮质素转运蛋白：一种血浆中的皮质类固醇结合蛋白。II. 不同条件下的水平及雌激素的影响。
J Clin Invest. 1959 Aug;38(8):1290-7. doi: 10.1172/JCI103904.
10
Physiological disposition of 4-C14-cortisol during late pregnancy.孕晚期4-C14-皮质醇的生理处置
J Clin Invest. 1957 Sep;36(9):1350-62. doi: 10.1172/JCI103534.