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萘普生与吲哚美辛治疗运动损伤的双盲对照试验。

A double-glind comparative trial of naproxen and indomethacin in sports injuries.

作者信息

Williams J G, Engler C

出版信息

Rheumatol Rehabil. 1977 Nov;16(4):265-69. doi: 10.1093/rheumatology/16.4.265.

Abstract

Fifty patients suffering from sports injuries were included in a double-blind trial comparing the efficacy and side-effects of naproxen and indomethacin. The patients' daily record cards showed that the number of patients whose paine cleared in less than seven days was statistically significantly greater in the naproxen grout (P = 0.03). Overall change at the seven-day follow-up visit, changes in the degree of pain, swelling and limitation of movement, as well as the number of patients ready for full activity at seven days were also greater in the naproxen group. However, the differences between the two groups of treatment did not reach statistical significance. The number of side-effects was equal in both treatment groups. One patient on indomethacin had to be withdrawn from the trial after two days' treatment, because of severe gastric pains.

摘要

五十名患有运动损伤的患者被纳入一项双盲试验,比较萘普生和吲哚美辛的疗效及副作用。患者的每日记录卡显示,在萘普生组中,疼痛在不到七天内缓解的患者数量在统计学上显著更多(P = 0.03)。在七天的随访中,萘普生组的总体变化、疼痛程度、肿胀和活动受限程度的变化,以及七天时准备好完全恢复活动的患者数量也更大。然而,两组治疗之间的差异未达到统计学意义。两个治疗组的副作用数量相等。一名使用吲哚美辛的患者在治疗两天后因严重胃痛不得不退出试验。

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