由格罗斯白血病病毒在体外诱导的大鼠胸腺细胞的肿瘤转化。
Neoplastic transformation of rat thymic cells induced in vitro by Gross leukemia virus.
作者信息
Ioachim H L
出版信息
Science. 1967 Feb 3;155(3762):585-7. doi: 10.1126/science.155.3762.585.
PMID:6015876
Abstract
Cultures of embryonal rat thymus infected initially with Gross leukemia virus have, at the present time, abundantly replicated infectious virus particles for 20 months. Cells from these cultures, after 3 months in vitro, displayed morphological changes and induced formation of tumors upon isotransplantation. The tumors were serially transplantable, and subsequent transplants continue to carry the initial Gross leukemia virus.
摘要
最初感染格罗斯白血病病毒的胚胎大鼠胸腺培养物，目前已大量复制感染性病毒颗粒达20个月。这些培养物的细胞在体外培养3个月后，出现形态变化，并在同基因移植时诱导肿瘤形成。这些肿瘤可连续传代移植，后续移植继续携带最初的格罗斯白血病病毒。
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