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Regional mapping of human genes for hexosaminidase B and diphtheria toxin sensitivity on chromosome 5 using mouse X human hybrid cells.

作者信息

George D L, Francke U

出版信息

Somatic Cell Genet. 1977 Nov;3(6):629-38. doi: 10.1007/BF01539070.

DOI:10.1007/BF01539070
PMID:601683
Abstract

Mouse 3T3 (TK-) cells were fused to human leukocytes containing a balanced translocation [ins(3;5) (q27;q13q15)] in which part of the long arm of a chromosome 5 has been inserted into the long arm of a chromosome 3. Two independent, primary hybrid clones (XVI-10C;XVI-18A) retained the deleted chromosome 5 [del(5) (q13q15)] translocation product and were informative for regional mapping on chromosome 5 of genes involved in expression of hexosaminidase B (HEXB) and diphtheria toxin sensitivity (DTS). Both XVI-10C and XVI-18A clones were sensitive to diphtheria toxin. Toxin-resistant derivatives of these clones (XVI-10C DTR; XVI-18A DTR) were analyzed for chromosome content and expression of Hex B activity, as were XVI-10C and XVI-18A cells which had not been exposed to diphtheria toxin. The results of this study provide evidence for localization of DTS to region 5q15 leads to 5 qter on the long arm of chromosome 5, and localization of HEXB to region 5pter leads to 5q13.

摘要

相似文献

1
Regional mapping of human genes for hexosaminidase B and diphtheria toxin sensitivity on chromosome 5 using mouse X human hybrid cells.
Somatic Cell Genet. 1977 Nov;3(6):629-38. doi: 10.1007/BF01539070.
2
Regional assignment of the gene for diphtheria toxin sensitivity using subchromosomal fragments in microcell hybrids.利用微细胞杂种中的亚染色体片段对白喉毒素敏感性基因进行区域定位。
Chromosoma. 1987;96(1):26-32. doi: 10.1007/BF00285879.
3
Regional localization of alpha-galactosidase (GLA) to Xpter----q22, hexosaminidase B (HEXB) to 5q13----qter, and arylsulfatase B (ARSB) to 5pter----q13.α-半乳糖苷酶（GLA）定位于Xpter----q22区域，己糖胺酶B（HEXB）定位于5q13----qter区域，芳基硫酸酯酶B（ARSB）定位于5pter----q13区域。
Cytogenet Cell Genet. 1984;38(1):45-9. doi: 10.1159/000132028.
4
Genetic analysis of the cell surface: association of human chromosome 5 with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids.细胞表面的遗传分析：人类5号染色体与小鼠-人类体细胞杂种对白喉毒素敏感性的关联。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2237-41. doi: 10.1073/pnas.72.6.2237.
5
Regional localization of the genes for human HEXB. PGK, GALA. HPRT, G6PD by somatic cell hybridization.通过体细胞杂交对人类己糖胺酶B、磷酸甘油酸激酶、半乳糖激酶、次黄嘌呤-鸟嘌呤磷酸核糖转移酶、葡萄糖-6-磷酸脱氢酶基因进行区域定位。
Ann Genet. 1981;24(2):89-92.
6
Evidence for localization of the gene for hexosaminidase B to the cen leads to q13 region of human chromosome 5 using mouse x human hybrid cells.利用小鼠与人的杂交细胞，将β-N-乙酰氨基己糖苷酶B基因定位于人类第5号染色体cen至q13区域的证据。
Cytogenet Cell Genet. 1978;22(1-6):408-11. doi: 10.1159/000130984.
7
[Further steps in regional localization of the gene coding for human arylsulfatase B (ARSB): gene assignment to the section q11-qter of chromosome 5].[人类芳基硫酸酯酶B（ARSB）编码基因区域定位的进一步步骤：基因定位于5号染色体q11-qter区段]
Probl Med Wieku Rozwoj. 1990;16:163-5.
8
Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria toxin selection, and the linkage of hexosaminidase-A, mannose phosphate isomerase, and pyruvate kinase (M2).己糖胺酶B定位于5号染色体、经白喉毒素筛选后的分离情况以及己糖胺酶A、磷酸甘露糖异构酶和丙酮酸激酶（M2）的连锁关系
Cytogenet Cell Genet. 1976;16(1-5):188-91. doi: 10.1159/000130587.
9
Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria toxin selection, and the linkage of hexosaminidase-A, mannose phosphate isomerase, and pyruvate kinase (M2).己糖胺酶B定位于5号染色体、经白喉毒素选择后的分离以及己糖胺酶A、磷酸甘露糖异构酶和丙酮酸激酶（M2）的连锁关系
Birth Defects Orig Artic Ser. 1976;12(7):188-91.
10
Diphtheria toxin sensitivity in a monochromosomal hybrid containing human chromosome 5.含有人类5号染色体的单染色体杂种中的白喉毒素敏感性
J Hered. 1985 Sep-Oct;76(5):329-34.

引用本文的文献

1
Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11.
Mamm Genome. 1994 Apr;5(4):211-5. doi: 10.1007/BF00360547.
2
Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.人-中国仓鼠细胞杂种中的选择性连锁破坏：人类5号染色体上leuS、hexB、emtB和chr基因的缺失定位
Mol Cell Biol. 1982 Oct;2(10):1220-8. doi: 10.1128/mcb.2.10.1220-1228.1982.
3
Assignment of the gene for acid beta-glucosidase to human chromosome 1.酸性β-葡萄糖苷酶基因定位于人类第1号染色体。
Am J Hum Genet. 1981 Jul;33(4):564-75.
4
Regional assignment of the structural gene for human alpha-L-iduronidase.人类α-L-艾杜糖醛酸酶结构基因的区域定位
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1169-73. doi: 10.1073/pnas.81.4.1169.
5
Isolation and characterization of cloned human DNA fragments carrying reiterated sequences common to both autosomes and the X chromosome.携带常染色体和X染色体共有的重复序列的克隆化人类DNA片段的分离与特性分析。
Nucleic Acids Res. 1981 Apr 24;9(8):1853-72. doi: 10.1093/nar/9.8.1853.
6
The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter.生长激素基因和绒毛膜生长催乳素基因位于人类第17号染色体长臂的q21至qter区域。
Hum Genet. 1981;57(2):138-41. doi: 10.1007/BF00282009.
7
Assignment of the human gene for the glucocorticoid receptor to chromosome 5.将人类糖皮质激素受体基因定位于5号染色体。
Proc Natl Acad Sci U S A. 1985 Jun;82(11):3751-5. doi: 10.1073/pnas.82.11.3751.
8
The human C-reactive protein gene (CRP) and serum amyloid P component gene (APCS) are located on the proximal long arm of chromosome 1.人类C反应蛋白基因（CRP）和血清淀粉样蛋白P成分基因（APCS）位于1号染色体长臂近端。
Immunogenetics. 1986;24(3):171-6. doi: 10.1007/BF00364745.
9
Molecular cloning of cDNAs encoding rat and human medium-chain acyl-CoA dehydrogenase and assignment of the gene to human chromosome 1.编码大鼠和人中等链长酰基辅酶A脱氢酶的cDNA的分子克隆及该基因在人染色体1上的定位。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6543-7. doi: 10.1073/pnas.83.17.6543.
10
Deletion mapping of human chromosome 5 using chromosome-specific DNA probes.使用染色体特异性DNA探针进行人类5号染色体的缺失图谱分析。
Am J Hum Genet. 1985 Sep;37(5):839-52.