Unanue E R, Dixon F J, Feldman J D
J Exp Med. 1967 Jan 1;125(1):163-76. doi: 10.1084/jem.125.1.163.
Rabbits immunized to several homologous renal antigens developed a variety of autoantikidney antibodies. Some of these antibodies reacted with the host's glomeruli and appeared to cause glomerulonephritis. Passive transfer of sera from some of these nephritic rabbits into normal, unilaterally nephrectomized rabbits led to the induction of nephritis. The production of autoantibody to glomeruli was transitory in most instances in spite of continued immunization. In some rabbits immunized to whole kidney homogenate, extracts or sediment, antibodies were found fixed to renal tubular basement membranes where an ultrastructural lesion was demonstrated. Rabbits also produced antikidney antibody apparently to tubular cytoplasmic components which did not fix to kidney in vivo and were of no pathogenetic significance. Immunization with autologous renal basement membranes induced a small autoantibody response in half the rabbits. This response was not associated with detectable renal injury.
用几种同源肾抗原免疫的兔子产生了多种自身抗肾抗体。其中一些抗体与宿主的肾小球发生反应，似乎导致了肾小球肾炎。将一些患肾炎兔子的血清被动转移到正常的、单侧肾切除的兔子体内，可诱发肾炎。尽管持续免疫，但在大多数情况下，针对肾小球的自身抗体的产生是短暂的。在一些用全肾匀浆、提取物或沉淀物免疫的兔子中，发现抗体固定在肾小管基底膜上，在那里显示出超微结构损伤。兔子还产生了明显针对肾小管细胞质成分的抗肾抗体，这些抗体在体内不与肾脏结合，没有致病意义。用自体肾基底膜免疫，半数兔子产生了微弱的自身抗体反应。这种反应与可检测到的肾损伤无关。
