• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

正常人体内的血液铁动力学

Blood ferrokinetics in normal man.

作者信息

Hosain F, Marsaglia G, Finch C A

出版信息

J Clin Invest. 1967 Jan;46(1):1-9. doi: 10.1172/JCI105501.

DOI:10.1172/JCI105501
PMID:6018746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC297014/
Abstract

The clearance of radioiron from plasma and its appearance in circulating erythrocytes in normal subjects are studied. The importance of correcting for plasma iron fluctuations and for mean body hematocrit is illustrated. The data are analyzed by probability theory to determine relationships between intravascular and extravascular iron. Two refluxes are described, one of about 7 particles of every 100 leaving the plasma, and the second of about 23. The return times of these are about 5 hours and 8 days, respectively.

摘要

对正常受试者血浆中放射性铁的清除及其在循环红细胞中的出现情况进行了研究。阐述了校正血浆铁波动和平均身体血细胞比容的重要性。通过概率论对数据进行分析,以确定血管内铁与血管外铁之间的关系。描述了两种反流情况,一种是每100个离开血浆的粒子中约有7个发生反流,另一种约为23个。它们的返回时间分别约为5小时和8天。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f0/297014/9dfce918a981/jcinvest00229-0025-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f0/297014/cbea8acb885a/jcinvest00229-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f0/297014/9dfce918a981/jcinvest00229-0025-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f0/297014/cbea8acb885a/jcinvest00229-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f0/297014/9dfce918a981/jcinvest00229-0025-b.jpg

相似文献

1
Blood ferrokinetics in normal man.正常人体内的血液铁动力学
J Clin Invest. 1967 Jan;46(1):1-9. doi: 10.1172/JCI105501.
2
Ferrokinetics: a biologic model for plasma iron exchange in man.铁动力学:人体血浆铁交换的生物学模型。
J Clin Invest. 1970 Feb;49(2):197-205. doi: 10.1172/JCI106228.
3
Ferrokinetics in patients suffering from chronic renal disease and anaemia.慢性肾病和贫血患者的铁动力学
Scand J Haematol. 1967;4(1):33-45. doi: 10.1111/j.1600-0609.1967.tb01595.x.
4
Microtechnique for the study of ferro- and erythrokinetics in the rat.大鼠铁动力学和红细胞动力学研究的显微技术
Am J Vet Res. 1973 Feb;34(2):253-9.
5
Total body haematocrit iron kinetics and erythrocyte life span in pigeons (Columba livia).鸽子(家鸽)的全身血细胞比容铁动力学和红细胞寿命
Comp Biochem Physiol A Comp Physiol. 1989;92(2):215-8. doi: 10.1016/0300-9629(89)90156-4.
6
CLEARANCE OF IRON FROM HEMOCHROMATOTIC AND NORMAL TRANSFERRIN IN VIVO.体内血色沉着病性转铁蛋白和正常转铁蛋白对铁的清除
Blood. 1964 Dec;24:765-9.
7
[Effect of chloramphenicol on hematopoiesis in cases of reduced kidney function].[氯霉素对肾功能减退患者造血功能的影响]
Dtsch Med Wochenschr. 1970 Oct 2;95(40):2019-25. doi: 10.1055/s-0028-1108772.
8
[Clinical studies on ferrokinetics. II. Studies on erythokinetics with radioiron-a consideration on the pathogenesis of anemias].铁动力学的临床研究。II. 放射性铁对红细胞动力学的研究——对贫血发病机制的思考
Tokyo Igaku Zasshi. 1962 Oct;70:265-304.
9
Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport.储存铁动力学。VII。网状内皮系统铁转运的生物学模型。
J Clin Invest. 1974 Jun;53(6):1527-33. doi: 10.1172/JCI107703.
10
Ferrokinetics in pregnancy. I. Fetus and newborn.孕期铁动力学。I. 胎儿与新生儿。
Am J Obstet Gynecol. 1970 Mar;106(5):699-702. doi: 10.1016/0002-9378(70)90392-3.

引用本文的文献

1
Assessing Human Iron Kinetics Using Stable Iron Isotopic Techniques.运用稳定铁同位素技术评估人体铁动力学。
Clin Pharmacokinet. 2024 Oct;63(10):1389-1405. doi: 10.1007/s40262-024-01421-z. Epub 2024 Oct 16.
2
Nature of storage iron turnover.储存铁周转的性质。
Nagoya J Med Sci. 2024 Aug;86(3):361-369. doi: 10.18999/nagjms.86.3.361.
3
Total Iron Absorbed from Iron-Biofortified Potatoes Is Higher than that from Nonbiofortified Potatoes: A Randomized Trial Using Stable Iron Isotopes in Women from the Peruvian Highlands.

本文引用的文献

1
Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders.正常受试者及患有各种造血系统疾病患者的血浆和红细胞铁周转率
J Clin Invest. 1950 Aug;29(8):1041-52. doi: 10.1172/JCI102335.
2
Ferrokinetics in normal persons and in patients having various erythropoietic disorders.正常人和患有各种红细胞生成障碍患者的铁动力学。
J Clin Invest. 1951 Dec;30(12:2):1512-26. doi: 10.1172/JCI102562.
3
Iron and protein kinetics studied by means of doubly labeled human crystalline transferrin.通过双标记人晶体转铁蛋白研究铁和蛋白质动力学。
铁强化马铃薯中吸收的总铁量高于非铁强化马铃薯:一项使用稳定铁同位素在秘鲁高地妇女中进行的随机试验。
J Nutr. 2023 Jun;153(6):1710-1717. doi: 10.1016/j.tjnut.2023.04.010. Epub 2023 Apr 13.
4
Absorption of iron from edible house crickets: a randomized crossover stable-isotope study in humans.食用家蟋蟀中铁的吸收:人体随机交叉稳定同位素研究。
Am J Clin Nutr. 2022 Oct 6;116(4):1146-1156. doi: 10.1093/ajcn/nqac223.
5
Iron Absorption from Bouillon Fortified with Iron-Enriched Aspergillus oryzae Is Higher Than That Fortified with Ferric Pyrophosphate in Young Women.富含铁的米曲霉强化肉汁中的铁吸收高于焦磷酸铁强化肉汁中的铁吸收。
J Nutr. 2020 May 1;150(5):1109-1115. doi: 10.1093/jn/nxaa035.
6
Liver Iron Retention Estimated from Utilization of Oral and Intravenous Radioiron in Various Anemias and Hemochromatosis in Humans.从口服和静脉内放射性铁在各种贫血症和人类血色病中的利用来估计肝脏铁潴留。
Int J Mol Sci. 2020 Feb 6;21(3):1077. doi: 10.3390/ijms21031077.
7
Iron bioavailability of a casein-based iron fortificant compared with that of ferrous sulfate in whole milk: a randomized trial with a crossover design in adult women.基于酪蛋白的铁强化剂与硫酸亚铁在全脂牛奶中的铁生物利用度比较:一项在成年女性中采用随机交叉设计的试验
Am J Clin Nutr. 2019 Dec 1;110(6):1362-1369. doi: 10.1093/ajcn/nqz237.
8
The bioavailability of iron picolinate is comparable to iron sulfate when fortified into a complementary fruit yogurt: a stable iron isotope study in young women.焦酸亚铁的生物利用度与强化到补充水果酸奶中的硫酸亚铁相当:一项对年轻女性的稳定铁同位素研究。
Eur J Nutr. 2020 Jun;59(4):1371-1378. doi: 10.1007/s00394-019-01989-4. Epub 2019 Jun 11.
9
Problems in Ferrokinetics: extra radio-iron fixation to red cells.铁动力学中的问题:红细胞对额外放射性铁的固定
Nagoya J Med Sci. 2018 Nov;80(4):475-485. doi: 10.18999/nagjms.80.4.475.
10
Pharmacokinetics of Ferric Pyrophosphate Citrate, a Novel Iron Salt, Administered Intravenously to Healthy Volunteers.柠檬酸铁焦磷酸盐(一种新型铁盐)静脉注射给健康志愿者后的药代动力学
J Clin Pharmacol. 2017 Mar;57(3):312-320. doi: 10.1002/jcph.819. Epub 2016 Oct 3.
J Clin Invest. 1961 Dec;40(12):2143-52. doi: 10.1172/JCI104440.
4
The determination of iron in plasma or serum.血浆或血清中铁的测定。
Biochem J. 1955 Apr;59(4):599-602. doi: 10.1042/bj0590599.
5
STUDIES IN IRON KINETICS. I. INTERPRETATION OF FERROKINETIC DATA IN MAN.铁动力学研究。I. 人体中铁动力学数据的解读。
J Mt Sinai Hosp N Y. 1965 May-Jun;32:262-304.
6
STUDIES OF PLASMA FE59 DISAPPEARANCE--A MANIFESTATION OF INEFFECTIVE ERYTHROPOIESIS AND OF HEMOLYSIS.血浆铁59消失的研究——无效红细胞生成和溶血的一种表现
Blood. 1965 Jun;25:976-89.
7
FERROKINETICS: A STUDY OF TRANSPORT IRON IN PLASMA.铁动力学:血浆中转运铁的研究。
J Lab Clin Med. 1964 Dec;64:905-12.
8
INCORPORATION OF RADIOIRON INTO MARROW HEME.放射性铁掺入骨髓血红素
J Lab Clin Med. 1964 Oct;64:574-80.
9
A SIMPLIFIED PROCEDURE FOR THE SIMULTANEOUS ASSAY OF FE55 AND FE59 IN A LIQUID SCINTILLATION SYSTEM.液体闪烁系统中同时测定Fe55和Fe59的简化程序
J Lab Clin Med. 1964 May;63:885-93.
10
Studies with doubly labeled iron. IV. Evidence for a second iron-binding system in plasma.双标记铁的研究。IV. 血浆中第二种铁结合系统的证据。
J Lab Clin Med. 1963 Feb;61:280-91.