Vella F, Cunningham T A
Can Med Assoc J. 1967 Feb 18;96(7):398-401.
On routine electrophoretic analyses on filter paper and starch gel in an alkaline or neutral medium, no abnormal hemoglobin fractions were found in the blood of 600 newborn infants or their mothers. Trace amounts of hemoglobin Barts were noted in many of the blood samples from newborns when the starch gels (phosphate buffer pH 7.0) were stained with a benzidine/H(2)O(2) reagent. In one infant, precocious cessation of synthesis of hemoglobin F was postulated to account for the small amounts of this hemoglobin found in a cord-blood specimen. Analysis of 15,000 blood samples from adults revealed two instances in which the hemoglobin F level was 20 and 35%, respectively. The former was attributed to a hereditary persistence of hemoglobin F, while the latter was associated with acute leukemia.In an addendum, the finding of an infant with an abnormal hemoglobin variant, resembling in many of its properties hemoglobin F Texas, is reported.
在碱性或中性介质中对滤纸和淀粉凝胶进行常规电泳分析时，在600名新生儿及其母亲的血液中未发现异常血红蛋白组分。当用联苯胺/H₂O₂试剂对淀粉凝胶（磷酸盐缓冲液pH 7.0）进行染色时，在许多新生儿的血液样本中都检测到了微量的血红蛋白Barts。在一名婴儿中，推测血红蛋白F合成过早停止是导致脐带血样本中该血红蛋白含量较少的原因。对15000份成人血液样本的分析发现了两例血红蛋白F水平分别为20%和35%的情况。前者归因于血红蛋白F的遗传性持续存在，而后者与急性白血病有关。在附录中，报告了一名患有异常血红蛋白变体的婴儿，其许多特性与德克萨斯血红蛋白F相似。
