Miller T A
Immunology. 1967 Feb;12(2):231-41.
The immunity of pups that had been double-vaccinated with X-irradiated larvae was passively and adoptively transferred to susceptible pups using serum or lymphoid cells, or serum and lymphoid cells. The immunity of recipient pups was demonstrated by a high degree of resistance to the establishment of adult hookworms after challenge inoculation of normal larvae. Variation in the efficiency of serum and cells to act as vehicles for transfer of immunity was noted in different experiments, and was probably associated with the age of donor pups. However, within each experiment the results were remarkably uniform and quantitative relationships were observed between dose rate of serum and cells and success of passive and adoptive immunization. Delayed hypersensitivity was transferred to recipient pups as shown by significant increases in skin thickness 24–48 hours after active penetration of hookworm larvae.
用经X射线照射的幼虫进行两次疫苗接种的幼崽的免疫力，通过血清或淋巴细胞，或血清和淋巴细胞，被动和主动转移给易感幼崽。在对正常幼虫进行攻击接种后，受体幼崽对成虫钩虫的建立具有高度抗性，这证明了其免疫力。在不同实验中，注意到血清和细胞作为免疫转移载体的效率存在差异，这可能与供体幼崽的年龄有关。然而，在每个实验中，结果都非常一致，并且观察到血清和细胞的剂量率与被动和主动免疫的成功之间存在定量关系。如在钩虫幼虫主动侵入后24 - 48小时皮肤厚度显著增加所示，迟发型超敏反应被转移给了受体幼崽。
