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实验性钩虫病研究:通过致敏胸腺细胞和骨髓细胞将获得性免疫转移给小鼠体内的犬钩虫。

Studies on experimental ancylostomiasis: transfer of acquired immunity to Ancylostoma caninum in mice through sensitized thymus and bone marrow cells.

作者信息

Kolhe N P, Lakshmi P N, Johri G N

出版信息

Experientia. 1979 Sep 15;35(9):1242-3. doi: 10.1007/BF01963314.

Abstract

An attempt has been made to transfer acquired immunity to Ancylostoma caninum infective larvae from infected Swiss albino female mice to nonimmune, isologous recipients of same sex, through immunized thymus and bone marrow cells. Immunized cells from donors infected with a single high dose of 1000 larvae were found to be more immunocompetent than cells from donors infected with a single, but low dose of 500 larvae.

摘要

已尝试通过免疫的胸腺细胞和骨髓细胞,将感染犬钩虫感染性幼虫的瑞士白化雌性小鼠所获得的免疫力,转移给同性别的非免疫同系受体。发现来自感染1000条幼虫单一高剂量的供体的免疫细胞,比来自感染500条幼虫单一低剂量的供体的细胞更具免疫活性。

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