Best E W, Walker C B, Baker P M, Delaquis F M, McGregor J T, McKenzie A C
Can Med Assoc J. 1967 Apr 15;96(15):1104-8.
The object of this study was to investigate the relationship between residence, occupation and smoking habits, and mortality from chronic diseases, particularly lung cancer. It was a prospective study, initiated by a questionnaire sent to Canadian veteran pension recipients. The study was based on the replies of 78,000 males and 14,000 females, together with data on the deaths occurring among these respondents over a six-year follow-up period-July 1, 1956 to January 30, 1962.The outstanding finding of this study was that cigarette smokers compared to non-smokers had excessive mortality, particularly from heart and circulatory diseases, lung cancer, and bronchitis and emphysema. The mortality ratios for heart and circulatory diseases were elevated even for those who smoked cigarettes less than five years, and remained relatively constant as the duration of smoking increased. The mortality ratios for lung cancer increased markedly as the duration of smoking increased. A small excess in mortality was noted among urban residents. An association between cause of death and occupation was not evident in this study.Findings based on the data on smoking collected in this study were incorporated into the Report of the U.S. Surgeon-General's Advisory Committee on Smoking and Health.
本研究的目的是调查居住情况、职业和吸烟习惯与慢性病死亡率,尤其是肺癌死亡率之间的关系。这是一项前瞻性研究,通过向加拿大退伍军人养老金领取者发放问卷启动。该研究基于78000名男性和14000名女性的回复,以及这些受访者在1956年7月1日至1962年1月30日六年随访期内的死亡数据。这项研究的突出发现是,与不吸烟者相比,吸烟者死亡率过高,尤其是死于心脏病、循环系统疾病、肺癌以及支气管炎和肺气肿。即使对于吸烟不到五年的人,心脏病和循环系统疾病的死亡率也有所升高,并且随着吸烟时间的增加保持相对稳定。肺癌的死亡率随着吸烟时间的增加而显著上升。城市居民的死亡率略高。本研究中未发现死亡原因与职业之间存在关联。基于本研究收集的吸烟数据得出的研究结果被纳入了美国卫生局局长吸烟与健康咨询委员会的报告中。