Solomon L M, Nadler N J
Can Med Assoc J. 1967 Apr 22;96(16):1147-50.
Since storage-time of administered noradrenaline in the skin of patients with atopic dermatitis may be prolonged, it would be of interest to demonstrate the site of uptake of noradrenaline-(14)C in atopic dermatitis as compared with other eczematous and normal skins. Two adult patients with longstanding atopic dermatitis, a patient with contact dermatitis to nickel and one with normal skin, were studied. Identical sites in the four patients were injected intradermally with 0.02 mug. DL-noradrenaline-7-(14)C acetate. An 8-mm. punch biopsy of the injected site was performed 24 hours later. Radioautographs were developed between three and 199 days, according to the technique of Kopriwa and Leblond.(2) At 199 days, the number of grains in atopic dermatitic skin was greater than in contact dermatitis or normal skin. There was a concentration of grains over arrectores pilorum muscles and the upper one-third of the epidermis of atopic skin. Grains were also visible in proximity to arteriolar walls. There were few grains visible in the control sections. The results confirm earlier studies suggesting that atopic dermatitic skin retains noradrenaline longer than other dermatoses. Noradrenaline concentrates in the arrectores pilorum muscles and the upper epidermis. These findings may explain the cutis anserina (goose-flesh) appearance in atopic dermatitis.
由于特应性皮炎患者皮肤中注射的去甲肾上腺素的储存时间可能会延长，因此与其他湿疹性皮肤和正常皮肤相比，证明特应性皮炎中去甲肾上腺素 -（14）C 的摄取部位将是一件有趣的事情。研究了两名患有长期特应性皮炎的成年患者、一名对镍过敏的接触性皮炎患者和一名皮肤正常的患者。在这四名患者的相同部位皮内注射 0.02 微克 DL - 去甲肾上腺素 -7-（14）C 醋酸盐。24 小时后对注射部位进行 8 毫米的打孔活检。根据 Kopriwa 和 Leblond 的技术（2），在三到 199 天之间制作放射自显影片。在 199 天时，特应性皮炎皮肤中的颗粒数量多于接触性皮炎或正常皮肤。在特应性皮肤的立毛肌和表皮上三分之一处有颗粒聚集。在小动脉壁附近也可见颗粒。在对照切片中可见的颗粒很少。结果证实了早期的研究，表明特应性皮炎皮肤比其他皮肤病更长时间地保留去甲肾上腺素。去甲肾上腺素集中在立毛肌和表皮上层。这些发现可能解释了特应性皮炎中的鸡皮疙瘩外观。
