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兔白细胞同源及异源抗血清的淋巴细胞转化活性。

Lymphocyte-transforming activity of homologous and heterologous antisera to rabbit leucocytes.

作者信息

Knight S, Ling N R

出版信息

Immunology. 1967 May;12(5):537-47.

PMID:6022089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409137/
Abstract

Two out of nine rabbits receiving a course of immunization with homologous leucocytes produced antisera which caused blast formation and stimulated DNA synthesis of donor lymphocytes . Of the seven rabbits which failed to produce active antisera three had received only a short immunization course. The active antisera `transformed' lymphocytes from some rabbits but not those of others. This stimulatory effect was not related to the red cell types or the γ-globulin allotypes of the rabbits. Heterologous antisera raised to rabbit leucocytes in rats and guinea-pigs were cytotoxic to rabbit leucocytes and also caused leucoagglutination but never stimulated DNA synthesis and blast formation.

摘要

用同源白细胞进行一个免疫疗程的9只兔子中，有2只产生了抗血清，该抗血清可引起母细胞形成并刺激供体淋巴细胞的DNA合成。在未能产生活性抗血清的7只兔子中，有3只只接受了短免疫疗程。活性抗血清能“转化”一些兔子的淋巴细胞，但不能“转化”其他兔子的淋巴细胞。这种刺激作用与兔子的红细胞类型或γ-球蛋白异型无关。在大鼠和豚鼠中产生的针对兔白细胞的异种抗血清对兔白细胞具有细胞毒性，也会引起白细胞凝集，但从未刺激DNA合成和母细胞形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f0/1409137/146d319e3643/immunology00412-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f0/1409137/d29b2cf3534d/immunology00412-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f0/1409137/146d319e3643/immunology00412-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f0/1409137/d29b2cf3534d/immunology00412-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f0/1409137/146d319e3643/immunology00412-0056-b.jpg

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引用本文的文献

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Further studies on the normal lymphocyte transfer test in man.关于人类正常淋巴细胞转移试验的进一步研究。
Br Med J. 1966 Feb 26;1(5486):509-14. doi: 10.1136/bmj.1.5486.509.
2
Quantitative studies of the sensitivity of normal and neoplastic mouse cells to the cytotoxic action of isoantibodies.正常和肿瘤小鼠细胞对同种抗体细胞毒性作用敏感性的定量研究。
J Exp Med. 1962 Mar 1;115(3):527-53. doi: 10.1084/jem.115.3.527.
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BLOOD GROUPS IN THE RABBIT. TWO ADDITIONAL ISOANTIBODIES AND THE RED CELL CANTIGENS THEY IDENTIFY.家兔的血型。另外两种同种抗体及其所识别的红细胞抗原。
Affinity of antigen for white cells and its relation to the induction of antibody formation.
抗原与白细胞的亲和力及其与抗体形成诱导的关系。
Bacteriol Rev. 1968 Dec;32(4 Pt 2):404-24.
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J Exp Med. 1965 Aug 1;122(2):423-40. doi: 10.1084/jem.122.2.423.
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PLATELET AND LEUKOCYTE ISOANTIGENS AND THEIR ANTIBODIES: SEROLOGIC PHYSIOLOGIC AND CLINICAL STUDIES.血小板和白细胞同种抗原及其抗体：血清学、生理学和临床研究
Prog Hematol. 1964;4:222-304.
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LYMPHOCYTE TRANSFORMATION AS AN IN-VITRO HISTOCOMPATIBILITY TEST.淋巴细胞转化作为一种体外组织相容性试验。
Lancet. 1965 Feb 27;1(7383):453-5. doi: 10.1016/s0140-6736(65)91587-4.
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Ann N Y Acad Sci. 1964 Nov 30;120:280-4. doi: 10.1111/j.1749-6632.1964.tb34726.x.
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