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不同年龄兔的血液、脾脏、胸腺和阑尾淋巴细胞对葡萄球菌滤液“体外”刺激反应的比较。

A comparison of the responses of lymphocytes from blood, spleen, thymus and appendix of rabbits of different ages to stimulation "in vitro" with staphylococcal filtrate.

作者信息

Knight S, Ling N R

出版信息

Clin Exp Immunol. 1969 Jun;4(6):667-84.

PMID:5784128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1579044/
Abstract

There are lymphocytes in the spleen, appendix, thymus and peripheral blood of unimmunized rabbits which are activated to a blast state by staphylococcal filtrate. Staphylococcal filtrate-responsive cells are present in the thymus of rabbits at birth and their appearance in spleen and appendix coincides with the lymphoid ontogeny of these tissues. Thymus lymphocytes survive less well than lymphocytes from peripheral blood but the temporal relationship of their responses to staphylococcal filtrate is similar. Spleen lymphocytes survive as well as peripheral lymphocytes. Spleens of most adult rabbits contain a population of lymphocytes which responds sooner to staphylococcal filtrate, in terms of tritiated thymidine incorporation, than peripheral lymphocytes from the same animal.

摘要

在未免疫的兔子的脾脏、阑尾、胸腺和外周血中存在淋巴细胞，这些淋巴细胞会被葡萄球菌滤液激活至母细胞状态。对葡萄球菌滤液有反应的细胞在兔子出生时就存在于胸腺中，它们在脾脏和阑尾中的出现与这些组织的淋巴组织个体发生相一致。胸腺淋巴细胞的存活情况不如外周血淋巴细胞，但它们对葡萄球菌滤液反应的时间关系相似。脾脏淋巴细胞的存活情况与外周淋巴细胞相同。大多数成年兔子的脾脏中含有一群淋巴细胞，就氚标记胸腺嘧啶核苷掺入而言，这群淋巴细胞比同一动物的外周淋巴细胞对葡萄球菌滤液的反应更快。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00a/1579044/89686f268aea/clinexpimmunol00343-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00a/1579044/ba2d670218f7/clinexpimmunol00343-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00a/1579044/89686f268aea/clinexpimmunol00343-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00a/1579044/ba2d670218f7/clinexpimmunol00343-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00a/1579044/89686f268aea/clinexpimmunol00343-0058-a.jpg

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Giemsa staining of autoradiograms prepared with stripping film.
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