Lough J, Metrakos J D
Can Med Assoc J. 1967 May 6;96(18):1258-61.
Idiopathic neonatal hepatitis is the uncommon syndrome of prolonged obstructive jaundice associated with giant cell transformation in the liver and patent bile ducts. Either hepatitis virus or an inherited abnormality has been suggested as a likely pathogenic agent for the syndrome.Recent observation of discordance for idiopathic neonatal hepatitis in monozygotic twins is felt to be inconsistent with either an infectious or a simple genetic etiology. Immaturity of the hepatic parenchymal cell bilirubin excretory pathway is postulated as a cause of jaundice in some of these babies.
特发性新生儿肝炎是一种罕见的综合征，表现为持续性梗阻性黄疸，伴有肝脏巨细胞转化和胆管通畅。有人提出肝炎病毒或遗传异常可能是该综合征的致病因素。最近观察到同卵双胞胎中特发性新生儿肝炎情况不一致，这被认为与感染性病因或简单的遗传病因均不相符。推测部分此类婴儿黄疸的病因是肝实质细胞胆红素排泄途径不成熟。
