特发性新生儿肝炎还是肝外胆道闭锁？肝活检的作用。
Idiopathic neonatal hepatitis or extrahepatic biliary atresia? The role of liver biopsy.
作者信息
Kheir Abdelmoneim Em, Ahmed Wisal Ma, Gaber Israa, Gafer Sara Ma, Yousif Badreldin M
机构信息
Department of Paediatrics and Child Health, Faculty of Medicine , University of Khartoum and Soba University Hospital , Sudan.
Department of Paediatrics , Soba University Hospital, Khartoum , Sudan.
出版信息
Sudan J Paediatr. 2016;16(1):58-62.
Cholestasis in early infancy represents a diagnostic dilemma and most of these infants suffer either from extrahepatic biliary atresia or idiopathic neonatal hepatitis. Differentiation between the two conditions may be extremely difficult both clinically and biochemically, and a diagnostic liver biopsy is usually required. We report on a Sudanese infant who presented at the age of 4 weeks with prolonged cholestatic jaundice, abdominal ultrasound was inconclusive, HIDA scan was suggestive of extrahepatic biliary atresia and the diagnosis of idiopathic neonatal hepatitis was only reached by liver biopsy. The infant made full recovery on supportive treatment during a one year follow up period.
婴儿早期胆汁淤积是一个诊断难题，这些婴儿大多患有肝外胆道闭锁或特发性新生儿肝炎。这两种情况在临床和生化方面的鉴别都可能极其困难，通常需要进行诊断性肝活检。我们报告一例苏丹婴儿，该婴儿4周龄时出现胆汁淤积性黄疸持续不退，腹部超声检查结果不明确，HIDA扫描提示肝外胆道闭锁，仅通过肝活检才确诊为特发性新生儿肝炎。在为期一年的随访期内，该婴儿经支持治疗后完全康复。
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