Zimmon D S
Yale J Biol Med. 1977 Sep-Oct;50(5):497-506.
The hepatic circulation is unique in that high volumes of low pressure blood flow are supplied through a dual venous and arterial circulation. This vascular supply is modulated both by the gastrointestinal vascular bed and an intrahepatic microcirculation. This complex vascular system is influenced by pathologic processes within the liver. Alterations in the hepatic circulation reflect hepatic metabolic adaptation and injury. It seems reasonable to assume that in some circumstances hepatic circulatory alterations are inappropriate, exaggerated or inadequate and contribute to the initiation or perpetuation of hepatic injury. This paper attempts to focus on evidence derived from studies of the normal and abnormal hepatic circulation that provide insights into hepatic circulatory responses and their role in the initiation and perpetuation of hepatic injury. A possible relationship of these vascular changes to pathologic processes within the liver is proposed. Ultimately, precise measurement and understanding of hepatic vasculature changes may allow appropriate intervention to offset injury or stimulate maximum effective repair.
肝循环的独特之处在于，通过双重静脉和动脉循环供应大量低压血流。这种血管供应受到胃肠血管床和肝内微循环的调节。这个复杂的血管系统受到肝脏内病理过程的影响。肝循环的改变反映了肝脏的代谢适应和损伤。可以合理推测，在某些情况下，肝循环改变是不适当的、过度的或不足的，并导致肝损伤的起始或持续。本文试图聚焦于来自正常和异常肝循环研究的证据，这些证据有助于深入了解肝循环反应及其在肝损伤起始和持续中的作用。文中提出了这些血管变化与肝脏内病理过程之间可能的关系。最终，对肝血管变化的精确测量和理解可能会允许进行适当干预，以抵消损伤或刺激最大程度的有效修复。
