Zabel M
Z Hautkr. 1977 Dec 15;52(24):1253-8.
The histopathology of erythema nodosum is discussed with reference to the literature and of 19 cases of our clinic. There is a significant vascular involvement especially of the subcutaneous tissue. The veins and arteries are equally affected. The histological picture consists not only of an acute inflammatory process in the subcutaneous tissue, but also of inflammatory cells which area see to a lesser extent in the dermis. In many cases the typical small granulomatous foci of MIESCHER which are considered to be pathognomonic for erythema nodosum do not develop. In the cases which we examined we were not always able to tell from the histological picture how long the erythema nodosum had been present. Multinucleated giant cells which are often found in the septal connective tissue are seen even in relatively acute cases.
结合文献及本诊所的19例病例，对结节性红斑的组织病理学进行了讨论。存在显著的血管受累情况，尤其是皮下组织。静脉和动脉均受到同等程度的影响。组织学表现不仅包括皮下组织的急性炎症过程，还包括在真皮中程度较轻可见的炎症细胞。在许多病例中，被认为是结节性红斑特征性表现的典型小肉芽肿灶并未形成。在我们检查的病例中，我们并不总是能够从组织学图像判断结节性红斑已经存在了多长时间。即使在相对急性的病例中，也可见到常在间隔结缔组织中发现的多核巨细胞。
