Cohen E L, Conn J W, Rovner D R
J Clin Invest. 1967 Mar;46(3):418-28. doi: 10.1172/JCI105543.
Peripheral plasma renin activity and aldosterone excretion rates have been measured in normal people during recumbency, recumbent exercise, tilting, and continuous ambulation. Upright posture induces a prompt elevation in peripheral plasma renin activity beginning in 15 minutes and peaking between 60 and 120 minutes. Aldosterone excretion is increased during 120 minutes of upright posture and correlates directly with the elevation in renin activity. Upright posture induces increased plasma renin activity regardless of the level of sodium intake in the preparatory diet. Concomitant measurements of endogenous creatinine clearance and the rates of excretion of sodium and potassium suggest that a fall in renal arterial perfusion resulting from upright posture induces increased release of renin and the subsequent secondary stimulation of aldosterone secretion. Our data indicate that the changes in plasma renin activity are due to changes in the amount of the enzyme rather than to changes in other elements of the reninangiotensin systm. This report discusses the physiologic importance of postural augmentation of renin production, emphasizing that for proper interpretation of values of plasma renin activity, posture as well as dietary factors must be considered and controlled.
已对正常人在卧位、卧位运动、倾斜和持续行走期间的外周血浆肾素活性和醛固酮排泄率进行了测量。直立姿势会使外周血浆肾素活性迅速升高，15分钟开始，60至120分钟达到峰值。直立姿势120分钟期间醛固酮排泄增加，且与肾素活性升高直接相关。无论准备饮食中的钠摄入量如何，直立姿势都会导致血浆肾素活性增加。同时测量内生肌酐清除率以及钠和钾的排泄率表明，直立姿势导致的肾动脉灌注下降会促使肾素释放增加，进而继发刺激醛固酮分泌。我们的数据表明，血浆肾素活性的变化是由于酶量的变化，而非肾素 - 血管紧张素系统其他成分的变化。本报告讨论了肾素生成姿势性增强的生理重要性，强调为了正确解释血浆肾素活性值，必须考虑并控制姿势以及饮食因素。
