腺病毒肿瘤系统中移植免疫的本质
On the nature of transplantation immunity in the adenovirus tumor system.
作者信息
Berman L D
出版信息
J Exp Med. 1967 Jun 1;125(6):983-1000. doi: 10.1084/jem.125.6.983.
Abstract
The existence of a virus-induced, virus-specific transplantation, antigen in adenovirus 12-induced CBA mouse tumors was demonstrated. The antigen is virus-specific, but not related to structural virion or T antigens. It is a weak antigen, and required immunization with whole, infectious adenovirus 12 to produce considerable immunity. Comparable immunity could not be achieved with homologous cellular or subcellular materials, but some indication of enhancement was produced with low tumor dose. Immunization required at least 2 wk and was mediated by immune lymphoid cells. Serum of immunized animals showed no demonstrable cytotoxicity or enhancement. Animals immunized with virus and Freund's adjuvant showed diminished transplantation immunity, although these animals were actively immunized against adenovirus type 12 structural virion antigens.
摘要
已证实，在腺病毒12诱发的CBA小鼠肿瘤中存在一种病毒诱导的、病毒特异性移植抗原。该抗原具有病毒特异性，但与病毒粒子结构或T抗原无关。它是一种弱抗原，需要用完整的、具有感染性的腺病毒12进行免疫才能产生相当的免疫力。用同源细胞或亚细胞物质无法获得类似的免疫力，但低剂量肿瘤可产生一定程度的增强作用。免疫至少需要2周时间，且由免疫淋巴细胞介导。免疫动物的血清未显示出可检测到的细胞毒性或增强作用。用病毒和弗氏佐剂免疫的动物显示移植免疫力降低，尽管这些动物已主动免疫了腺病毒12型病毒粒子结构抗原。
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