Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1936 Jun 30;64(1):63-77. doi: 10.1084/jem.64.1.63.
A method has been devised for serological tests with a virus producing rabbit papillomas that become carcinomatous. The discrete character of the growths caused by the virus when suitably diluted fits it notably for quantitative experimentation. It shows no tendency to lie latent in domestic rabbits though it does so on occasion in cottontails, the natural hosts. Sera which partially neutralize it do not alter its character, or attenuate it, but merely cut down the number of its effective entities. The serum of normal domestic rabbits is ordinarily devoid of neutralizing influence on the virus, but that of animals carrying the papillomas usually exhibits neutralizing power soon after these appear. The rate at which this power increases depends in general upon the amount of papillomatous tissue developing, but exceptions to the rule occur, the presence of fairly large growths being compatible with a lack of such powers in demonstrable amount. Even when the antiviral power is great it has no evident influence on the course of established papillomas, other factors determining whether these enlarge or retrogress. It acts to prevent successful reinoculation of the animal, however.
已经设计出一种针对产生癌变兔子乳头瘤病毒的血清学检测方法。病毒的适当稀释后会产生离散的生长特征，非常适合定量实验。尽管该病毒有时会在棉尾兔（其自然宿主）中潜伏，但在家兔中不会。部分中和它的血清不会改变其特征或使其减毒，而只是减少其有效实体的数量。正常家兔的血清通常对该病毒没有中和作用，但携带乳头瘤的动物的血清通常在这些肿瘤出现后不久就表现出中和能力。这种能力增加的速度通常取决于乳头瘤组织的发展程度，但也会出现例外，相当大的肿瘤存在与可证明数量的这种能力缺乏兼容。即使抗病毒能力很强，它对已建立的乳头瘤的发展也没有明显的影响，其他因素决定了这些肿瘤是增大还是退化。然而，它可以防止动物成功再次接种。
