Elnäs S, Joelsson I, Lewander R, Lundqvist H, Lunell N O, Sarby B, Aström H
Acta Obstet Gynecol Scand. 1977;56(4):297-301. doi: 10.3109/00016347709154982.
The influence of salbutamol, a beta-2-receptor-stimulating agent, on the blood flow through the utero-placental unit was evaluated in the human. Serial placenta scintigrams were analysed quantitatively, after injection of 0.5 mCi Indium-113m, by means of a gamma-camera connected on line to a computer. The examinations were performed in the third trimester of pregnancy. No sedation was used. Uterine contractions were not present. Salbutamol caused an increase in activity over the placental region, corresponding to a 15% increase in blood volume. The rise time of the initial phase of isotope accumulation (calculated from 5 to 95% of final activity) was prolonged by 100% during salbutamol infusion. As the rise time is proportional to the volume/flow ratio of blood in the uteroplacental region, our data indicate that salbutamol infusion causes a decrease in blood flow in the absence of uterine contractions.
在人体中评估了β2受体激动剂沙丁胺醇对子宫胎盘单位血流的影响。在注射0.5毫居里铟-113m后，通过与计算机联机的γ相机对系列胎盘闪烁图进行定量分析。检查在妊娠晚期进行。未使用镇静剂。未出现子宫收缩。沙丁胺醇使胎盘区域的活性增加，相当于血容量增加15%。在输注沙丁胺醇期间，同位素蓄积初始阶段的上升时间（从最终活性的5%计算至95%）延长了100%。由于上升时间与子宫胎盘区域血液的容量/流量比成正比，我们的数据表明，在无子宫收缩的情况下，输注沙丁胺醇会导致血流减少。
