Hayslett J P, Kashgarian M, Epstein F H
J Clin Invest. 1967 Jul;46(7):1254-63. doi: 10.1172/JCI105618.
Acute infusions of isotonic saline in the rat cause an increase in glomerular filtration rate and in the excretion of salt and water. The kidney swells, due to expansion of tubular and interstitial volume. Despite the increase in tubular diameter, transit time through the proximal tubules and loops of Henle is decreased, presumably owing to a greatly accelerated rate of tubular flow. Proximal tubular reabsorption, measured in blocked tubules, is inhibited in a way that cannot be ascribed to changes in tubular diameter. The prolongation of proximal reabsorptive half-time is not affected by the administration of aldosterone. It occurs equally in rats chronically loaded with or deprived of salt, and it is therefore not likely that it is influenced by the renal content of renin. In contrast, reabsorption from the distal convoluted tubule is enhanced by saline infusion. This change is observed in segments of tubules blocked with oil and isolated from their glomeruli and thus appears to occur independently of changes in glomerular filtration or tubular flow.
给大鼠急性输注等渗盐水会导致肾小球滤过率以及盐和水排泄增加。由于肾小管和间质体积增大，肾脏会肿胀。尽管肾小管直径增大，但通过近端小管和亨利氏袢的转运时间却缩短了，推测这是由于肾小管流速大幅加快所致。在阻塞的肾小管中测量近端肾小管重吸收，其受到抑制的方式无法归因于肾小管直径的变化。近端重吸收半衰期的延长不受醛固酮给药的影响。它在长期摄入盐分或缺乏盐分的大鼠中同样会发生，因此不太可能受肾素肾含量的影响。相比之下，输注盐水会增强远曲小管的重吸收。这种变化在被油阻塞且与肾小球分离的肾小管节段中观察到，因此似乎独立于肾小球滤过或肾小管流速的变化而发生。
