Ahlgren M, Lindberg L G, Nordqvist S R
Acta Obstet Gynecol Scand. 1977;56(5):531-4. doi: 10.3109/00016347709155026.
Local excision of severe dysplasia or carcinoma in situ of the uterine cervix by punch biopsies was the treatment in 366 cases. In 61%, cervical cytology reverted to negative or slight atypia. 153 patients have been followed from 1 to 7 years. Failures to remove the entire lesion were discovered within the first year of follow-up in all cases but 10. Complications were negligible and no patients have subsequently developed invasive cancer of the cervix. Selective local excision as an alternative to other minimally traumatic techniques, e.g. cryotherapy is discussed. Although the failure rate is slightly higher with local excision, an obvious advantage is the availability of all removed tissue for histopathologic diagnosis. Thus, the risk of overlooking microinvasive disease is reduced to a minimum.
通过活检对366例子宫颈重度发育异常或原位癌进行局部切除。61%的患者宫颈细胞学检查恢复为阴性或轻度异型性。153例患者已随访1至7年。除10例患者外，所有病例均在随访的第一年内发现未能切除全部病变。并发症可忽略不计，且随后没有患者发生宫颈浸润癌。文中讨论了选择性局部切除作为其他微创技术（如冷冻疗法）替代方法的情况。尽管局部切除的失败率略高，但一个明显的优点是所有切除组织都可用于组织病理学诊断。因此，将漏诊微浸润性疾病的风险降至最低。
