Gerber G B, Dancewicz A M, Bessemans B, Casale G
Acta Radiol Ther Phys Biol. 1977 Oct;16(5):447-55. doi: 10.3109/02841867709133966.
The right hemithorax of rats was exposed to 1 kR of roentgen rays, the animals were killed at different times, and various physiologic and biochemic parameters (DNA, protein, collagen, sialic acid, lysosomal enzymes, fibrinolytic activity, peroxides and blood flow ratio between irradiated and non irradiated lung) were determined from 1 day until 11 months after irradiation. A decrease in relative blood flow was observed from 2 weeks until 11 months, a decrease in phospholipids from one to 3 months and a decrease in fibrinolytic activity from 1 day to 11 months after irradiation. At several times a decrease in sialic acid and cathepsin D was also noted. The changes are discussed with respect to the pathogenetic mechanisms of late lung damage.
将大鼠右半胸暴露于1千伦琴的X射线下，在不同时间处死动物，并测定照射后1天至11个月期间的各种生理和生化参数（DNA、蛋白质、胶原蛋白、唾液酸、溶酶体酶、纤溶活性、过氧化物以及照射肺与未照射肺之间的血流比）。照射后2周直至11个月观察到相对血流减少，1至3个月磷脂减少，照射后1天至11个月纤溶活性降低。在几个时间点还观察到唾液酸和组织蛋白酶D减少。就晚期肺损伤的发病机制对这些变化进行了讨论。
