Ercan Z S, Türker R K
Agents Actions. 1977 Dec;7(5-6):569-72. doi: 10.1007/BF02111131.
Angiotensin II and its natural fragment (des-aspartic acid)1-angiotensin II (angiotensin III) induced a dose-dependent contraction in the isolated rat stomach fundus strip and rat colon. 1-Acetyl-2-(8-chloro-10,11-dihydrodibenz(b,f)(1,4)oxazepine-10, carbonyl) hydrazine (SC 19220), a widely used competitive-blocker of prostaglandins and acetyl salicylic acid, a well-known inhibitor of prostaglandin biosynthesis, partially abolished the contraction induced by both peptides in the rat stomach fundus but not in the rat colon. The inhibition induced by SC 19220 and acetyl salicylic acid was found to be higher for angiotensin III than angiotensin II when the dose-response curves and equipotent concentrations of the peptides were compared before and after the drugs. These results were taken as evidence that some component of the contractile effects of angiotensin II and angiotensin III on the isolated rat stomach fundus involves the release of prostaglandins by the peptides and in this respect angiotensin III has higher potency than angiotensin II.
血管紧张素II及其天然片段（去天冬氨酸）1 - 血管紧张素II（血管紧张素III）可使离体大鼠胃底条和大鼠结肠产生剂量依赖性收缩。1 - 乙酰基 - 2 - （8 - 氯 - 10,11 - 二氢二苯并（b，f）（1,4）恶唑并[4,3 - a]氮杂卓 - 10 - 羰基）肼（SC 19220），一种广泛使用的前列腺素竞争性阻滞剂，以及乙酰水杨酸，一种众所周知的前列腺素生物合成抑制剂，可部分消除两种肽在大鼠胃底引起的收缩，但对大鼠结肠无效。当比较给药前后肽的剂量 - 反应曲线和等效浓度时，发现SC 19220和乙酰水杨酸对血管紧张素III的抑制作用比对血管紧张素II的抑制作用更强。这些结果被视为证据，表明血管紧张素II和血管紧张素III对离体大鼠胃底的收缩作用的某些成分涉及肽类释放前列腺素，并且在这方面血管紧张素III比血管紧张素II具有更高的效力。
