An evaluation of the Guest method for determining erythrocyte sedimentation rate.

The Guest method for determining erythrocyte sedimentation rate was compared with the standard Westergren method. The Guest method consists of disposable plastic tubes with a method of filling with potentially infectious blood to avoid contact between the technician and the sample. Erythrocyte sedimentation rates were determined for samples containing normal and elevated fibrinogen levels. On the basis of the results of this study, the Guest method performed as well as the Westergren method in the population of healthy volunteers with normal fibrinogen levels and in the population of diseased individuals whose serum fibrinogen levels were elevated.