Ballou S P, Khan M A, Kushner I, Harris J W
Am J Hematol. 1977;2(4):397-402. doi: 10.1002/ajh.2830020410.
Although patients with hemolytic hemoglobinopathies characteristically are over-producers of urate, and hyperuricemia is frequently recognized, clinical gout has rarely been reported in such patients. Our evaluation of 2 premenopausal women with gout led to the diagnosis of previously unrecognized hemoglobinopathies (SC disease and CC disease). Investigation of these 2 patients and review of the reported cases of gout in patients with hemoglobin S or C disorders suggest that relatively minor abnormalities of renal function in these patients may lead to early development of significant hyperuricemia. With increasing lifespan of patients with hemolytic hemoglobinopathies and the likelihood of increased occurrence of renal function abnormalities, it is anticipated that gout will more frequently be responsible for joint symptoms in such patients.
虽然溶血性血红蛋白病患者通常尿酸生成过多，且高尿酸血症很常见，但这类患者中临床痛风的报道却很少。我们对2名绝经前痛风女性进行评估后，诊断出此前未被识别的血红蛋白病（SC病和CC病）。对这2例患者的调查以及对血红蛋白S或C异常患者痛风报告病例的回顾表明，这些患者相对轻微的肾功能异常可能导致早期显著高尿酸血症的发生。随着溶血性血红蛋白病患者寿命的延长以及肾功能异常发生率增加的可能性，预计痛风将更频繁地导致这类患者出现关节症状。
