Häntzschel U, Költzsch V
Z Gesamte Inn Med. 1978 Mar 15;33(6):180-4.
After a short survey of the purine metabolism, excretion of uric acid, theories of gout and urate nephropathy methodical references are given for the estimation of excretion of uric acid, a normal region on test persons was established and compared with other authors. The quantities of excretion and concentrations of uric acid from the 24 hours urine found on patients with asymptomatic hyperuricemia and manifest gout are the basis of the discussion of the diagnostic and therapeutic value of these examinations. In patients with gout and asymptomatic hyperuricemia the excretions of uric acid are a little higher than in healthy persons. A treatment with uricosuric remedies might not reduce the factor of risk hyperuricemia, since this does not lead to a prevention of the gout nephrophathy, on the contrary it furthers it.
在对嘌呤代谢、尿酸排泄、痛风理论和尿酸盐肾病进行简短综述后，给出了用于评估尿酸排泄的方法学参考文献，确定了测试人群的正常范围并与其他作者的结果进行了比较。无症状高尿酸血症和显性痛风患者24小时尿液中尿酸的排泄量和浓度是讨论这些检查的诊断和治疗价值的基础。痛风和无症状高尿酸血症患者的尿酸排泄量略高于健康人。使用促尿酸排泄药物进行治疗可能无法降低高尿酸血症的风险因素，因为这并不能预防痛风肾病，相反还会加重病情。
