Quigley H, Anderson D R
Invest Ophthalmol. 1976 Aug;15(8):606-16.
Axonal transport in primate optic nerve axons was studied by autoradiography, scintillation counting, and electron microscopy under conditions of short-term intraocular pressure elevation. With elevation of intraocular pressure to 30 mm. Hg below mean arterial blood pressure, blockage of transport was detected within 2 hours by autoradiography and within 1 hour by electron microscopy. The earliest buildup of radioactively labeled protein and ultrastructurally visible cellular organelles was within the scleral lamina cribrosa. The degree of blockage, judged by amount of label buildup, increased with time. Some transported material traversed the lamina cribrosa despite pressure elevation at the level tested. Reversal of transport blockade occurred rapidly after normalization of intraocular pressure.
在短期眼压升高的情况下，通过放射自显影、闪烁计数和电子显微镜研究了灵长类动物视神经轴突中的轴突运输。当眼压升高至低于平均动脉血压30毫米汞柱时，放射自显影在2小时内检测到运输受阻，电子显微镜在1小时内检测到运输受阻。放射性标记蛋白和超微结构可见细胞器最早在巩膜筛板处积聚。根据标记积聚量判断的阻塞程度随时间增加。尽管在测试水平存在压力升高，但一些运输物质仍穿过筛板。眼压恢复正常后，运输阻断迅速逆转。
