长链脂肪酸掺入大鼠大脑呼吸切片的磷脂中。
The incorporation of long-chain fatty acids into phospholipids of respiring slices of rat cerebrum.
作者信息
Webster G R
出版信息
Biochem J. 1967 Jan;102(1):373-80. doi: 10.1042/bj1020373.
Abstract
- Respiring slices of adult rat cerebrum have been shown to incorporate long-chain (14)C-labelled fatty acids into phospholipid. 2. Labelling was almost entirely confined to lecithin and ethanolamine phospholipid, only traces being present in serine phospholipid. 3. Palmitic acid, oleic acid and linoleic acid were incorporated more actively into lecithin than into ethanolamine phospholipid, but the converse was found with stearic acid. 4. All four acids labelled the 1- and 2-positions of both lipids; palmitic acid, oleic acid and linoleic acid were approximately evenly distributed, but stearic acid was incorporated predominantly at the 1-position. 5. It is considered that incorporation is most likely brought about through acylation of endogenously derived lysophosphatides. 6. The possible implications of this pathway of lipid metabolism in nervous tissue are discussed.
摘要
- 已证实成年大鼠大脑的呼吸切片能将长链（14）C标记的脂肪酸掺入磷脂中。2. 标记几乎完全局限于卵磷脂和乙醇胺磷脂，丝氨酸磷脂中仅有微量存在。3. 棕榈酸、油酸和亚油酸掺入卵磷脂的活性高于掺入乙醇胺磷脂，但硬脂酸的情况则相反。4. 所有四种酸都标记了两种脂质的1位和2位；棕榈酸、油酸和亚油酸分布大致均匀，但硬脂酸主要掺入1位。5. 据认为，掺入很可能是通过内源性溶血磷脂的酰化作用实现的。6. 讨论了这种脂质代谢途径在神经组织中的可能意义。
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