Neufeld H N, Rabinowitz B, Clejan S, Doman J
Angiology. 1977 Dec;28(12):853-64. doi: 10.1177/000331977702801206.
Serial determinations of creatine phosphokinase (CPK) isoenzymes were performed in 400 patients with definite acute myocardial infarction (AMI). The findings were correlated with the clinical course and the findings in another 300 cases of increased CPK levels. MB-CPK, the cardiac fraction, was present in all 400 cases of AMI and in only 5 cases of the 300 patients with high CPK due to causes other than AMI. Based on the magnitude and time course of the total CPK in relation to the MB-CPK, five different patterns are described which correlate with the clinical course. Our findings thus suggest that the determination of CPK isoenzymes can be a most helpful diagnostic tool in the care of the cardiac patient.
对400例确诊为急性心肌梗死（AMI）的患者进行了肌酸磷酸激酶（CPK）同工酶的系列测定。研究结果与临床病程相关，并与另外300例CPK水平升高的病例的研究结果进行了对比。心肌型CPK（MB-CPK）在所有400例AMI患者中均有出现，而在300例因AMI以外原因导致CPK升高的患者中仅5例出现。根据总CPK相对于MB-CPK的幅度和时间进程，描述了五种不同模式，这些模式与临床病程相关。因此，我们的研究结果表明，CPK同工酶的测定可能是心脏病患者护理中最有用的诊断工具。
