去甲肾上腺素对去极化肠平滑肌无机离子通透性的影响。
The effect of noradrenaline on the permeability of depolarized intestinal smooth muscle to inorganic ions.
作者信息
Jenkinson D H, Morton I K
出版信息
J Physiol. 1967 Feb;188(3):373-86. doi: 10.1113/jphysiol.1967.sp008144.
Abstract
- Radio-isotopes have been used to study the effect of noradrenaline on the permeability of the taenia of the guinea-pig caecum to inorganic ions. The preparations were bathed at either 10 or 20 degrees C in solutions containing a high concentration of potassium, in order to depolarize the fibres and so avoid ionic movements secondary to changes in membrane potential.2. Under these conditions noradrenaline increased both inward and outward fluxes of potassium whilst having little effect on the exchange of chloride.3. No effect of noradrenaline on the uptake of sodium could be detected, whereas carbachol (carbamyl choline chloride), applied under identical conditions, caused a significant increase at a concentration chosen to match the effect of noradrenaline on potassium exchange.4. These results are discussed in relation to the hypothesis that an increase in potassium permeability contributes to the inhibitory actions of noradrenaline on intestinal smooth muscle.
摘要
放射性同位素已被用于研究去甲肾上腺素对豚鼠盲肠带对无机离子通透性的影响。为使纤维去极化，从而避免因膜电位变化继发的离子运动，将标本置于含有高浓度钾的溶液中，在10或20摄氏度下进行孵育。
在这些条件下，去甲肾上腺素增加了钾的内向和外向通量，而对氯的交换影响很小。
未检测到去甲肾上腺素对钠摄取的影响，而在相同条件下应用的卡巴胆碱（氯化氨甲酰胆碱），在选择与去甲肾上腺素对钾交换作用效果相当的浓度时，可导致显著增加。
结合钾通透性增加有助于去甲肾上腺素对肠道平滑肌抑制作用的假说，对这些结果进行了讨论。
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