Heilman R D, Reo R R
Arch Int Pharmacodyn Ther. 1977 Dec;230(2):210-9.
The response of the rabbit perfused oviduct in vivo to phenylephrine (PE), isoproterenol (ISO) and epinephrine (EPI) was studied to determine if a purported change from alpha-adrenergic receptor dominance to beta-adrenergic receptor dominance during early gestation occurs (i.e. prior to implantation). The response of the tissue to PE did not change during early gestation, even in the presence of beta-receptor blockade by propranolol. The response to ISO of the PE-stimulated oviduct also did not change. However, the dose-response curve to EPI was shifted horizontally to the right 4 days after mating suggesting a tissue desensitization. It was concluded that the decreased oviductal sensitivity to EPI observed during early gestation could not be attributed to a change from alpha-receptor dominance to beta-receptor dominance.
研究了体内灌注的兔输卵管对去氧肾上腺素（PE）、异丙肾上腺素（ISO）和肾上腺素（EPI）的反应，以确定在妊娠早期（即着床前）是否发生了从α-肾上腺素能受体占主导地位到β-肾上腺素能受体占主导地位的所谓变化。即使在普萘洛尔阻断β受体的情况下，组织对PE的反应在妊娠早期也没有改变。PE刺激的输卵管对ISO的反应也没有改变。然而，交配后4天，对EPI的剂量反应曲线水平向右移动，表明组织脱敏。得出的结论是，妊娠早期观察到的输卵管对EPI敏感性降低不能归因于从α受体占主导地位到β受体占主导地位的变化。
