Hollenberg C H
J Lipid Res. 1967 Jul;8(4):328-34.
Adipose lipid obtained from fed rats 15 or 60 min after injection of radioactive glucose was separated into 10 triglyceride classes of differing fatty acid compositions. The distribution among these classes of total and radioactive triglyceride-glycerol was determined and found to be the same. Thus newly synthesized adipose triglycerides resemble in kind and proportion the triglycerides which exist in the tissue. This finding is in accord with the concept that the structures of adipose triglycerides are stable over long periods and that the turnover rate of the several triglyceride species are similar. After administration of radioactive glucose, the specific activity of saturated fatty acids was higher in the more saturated triglyceride species. These data indicate that newly formed saturated acids do not mix completely with all adipose tissue fatty acids available for esterification. Fatty acids derived from plasma triglyceride influenced the composition of newly synthesized adipose tissue triglyceride and thus constitute an important source of adipose tissue lipid.
从注射放射性葡萄糖后15或60分钟的喂食大鼠中获取的脂肪脂质被分离为10种不同脂肪酸组成的甘油三酯类别。测定了这些类别中总甘油三酯和放射性甘油三酯 - 甘油的分布，发现是相同的。因此，新合成的脂肪甘油三酯在种类和比例上类似于组织中存在的甘油三酯。这一发现与脂肪甘油三酯结构在长时间内稳定且几种甘油三酯种类的周转率相似的概念一致。给予放射性葡萄糖后，饱和度较高的甘油三酯种类中饱和脂肪酸的比活性更高。这些数据表明新形成的饱和酸不会与所有可用于酯化的脂肪组织脂肪酸完全混合。源自血浆甘油三酯的脂肪酸影响新合成的脂肪组织甘油三酯的组成，因此构成脂肪组织脂质的重要来源。
