Nicks R
Thorax. 1967 Jul;22(4):320-6. doi: 10.1136/thx.22.4.320.
The incidence and the outcome of systemic air embolism in 340 consecutive patients who underwent cardiac surgery under cardiopulmonary bypass in this unit for congenital defects of the cardiac septa and diseases involving the aortic and mitral valves have been studied. This was thought to have occurred in 40 patients, of whom 10 died. The distribution of air embolism according to the types of operation undertaken was as follows: six of 127 for atrial septal defect; six of 36 for ventricular septal defect; seven of 42 for mitral valve replacement; seven of 47 for aortic valve débridement; and 14 of 55 for aortic valve replacement. The cause was considered to have been systolic ejection of air into the aorta which, following cardiotomy, had been trapped in the pulmonary veins, the left atrium, the ventricular trabeculae, and the aortic root. Since the adoption of a more rigid `debubbling' routine, air embolism has not occurred. The incidence of pulmonary complications occurring in these patients after bypass was studied. Unilateral atelectasis, which occurred in five patients, resulted from retained bronchial secretions in all and was cured by bronchoscopic aspiration in all. The cause of bilateral atelectases, occurring in nine patients and fatal in eight of these, appeared to be related to cardiopulmonary factors and not to air embolism. Acute air injection made into the pulmonary artery of a dog resulted in pulmonary hypertension and a grossly deficient pulmonary circulation, but changes were largely resolved within a week. In view of this, it is considered that pulmonary air embolism may temporarily embarrass the right heart after the repair of a ventricular septal defect in a patient with an elevated pulmonary vascular resistance and diminished pulmonary vascular bed.
对本单位连续340例因先天性心脏间隔缺损及主动脉和二尖瓣疾病在体外循环下进行心脏手术的患者发生系统性空气栓塞的发生率及转归进行了研究。据认为,其中40例发生了空气栓塞,10例死亡。根据所进行的手术类型,空气栓塞的分布如下:房间隔缺损127例中有6例;室间隔缺损36例中有6例;二尖瓣置换术42例中有7例;主动脉瓣清创术47例中有7例;主动脉瓣置换术55例中有14例。其原因被认为是心脏切开术后空气收缩性喷射入主动脉,被困于肺静脉、左心房、心室小梁和主动脉根部。自从采用了更严格的“去泡”程序后,未再发生空气栓塞。对这些患者体外循环后发生肺部并发症的发生率进行了研究。5例患者发生的单侧肺不张均由支气管分泌物潴留引起,均经支气管镜吸引治愈。9例患者发生双侧肺不张,其中8例死亡,其原因似乎与心肺因素有关,而非空气栓塞。向犬肺动脉内急性注入空气导致肺动脉高压和肺循环严重不足,但一周内大部分变化得以缓解。鉴于此,认为在肺血管阻力升高和肺血管床减少的患者修复室间隔缺损后,肺空气栓塞可能会暂时使右心功能受困。