Peschle C, Magli M C, Cillo C, Lettieri F, Genovese A, Pizzella F, Soricelli A
Br J Haematol. 1977 Nov;37(3):345-52. doi: 10.1111/j.1365-2141.1977.tb01005.x.
The number of erythroid burst-(BFU-E) and colony-forming units (CFU-E), as well as of myeloid-macrophage colony-forming units (CFU-C), has been evaluated in tibial marrow and spleen of ex-hypoxic polycythaemic mice, at sequential time intervals after the end of hypoxia. In both marrow and spleen, the kinetics of the CFU-E pool is characterized by a sharp fall from above normal to lower than normal values. BFU-E and CFU-C however rise from below normal to higher than normal levels. These results have been correlated with both the erythropoietin (Ep) and the erythropoietic activity curves. It is apparent that Ep levels largely control both the differentiation and the amplification of the CFU-E pool and it is suggested that Ep may act as a 'survival factor' at the CFU-E level and/or increase the flow of cells from BFU-E to CFU-E. The difference in response between CFU-E and BFU-E favours a clearcut distinction between these populations, whereas the similarity between the BFU-E and CFU-C response suggest a close relationship between these two cell populations. It is also of interest that the murine spleen functions as a large reservoir of erythroid microenvironment for hypoxia-induced stress erythropoiesis.
在缺氧结束后的连续时间间隔内，对低氧后红细胞增多症小鼠的胫骨骨髓和脾脏中的红系爆式集落形成单位（BFU-E）、集落形成单位（CFU-E）以及髓系巨噬细胞集落形成单位（CFU-C）的数量进行了评估。在骨髓和脾脏中，CFU-E池的动力学特征是从高于正常水平急剧下降至低于正常水平。然而，BFU-E和CFU-C则从低于正常水平上升至高于正常水平。这些结果与促红细胞生成素（Ep）和红细胞生成活性曲线均相关。显然，Ep水平在很大程度上控制着CFU-E池的分化和扩增，并且有人提出Ep可能在CFU-E水平上作为一种“存活因子”发挥作用和/或增加细胞从BFU-E向CFU-E的流动。CFU-E和BFU-E之间反应的差异有利于明确区分这些细胞群体，而BFU-E和CFU-C反应之间的相似性表明这两个细胞群体之间存在密切关系。同样有趣的是，小鼠脾脏作为缺氧诱导应激性红细胞生成的红系微环境的一个大储存库发挥作用。
