心肌缺氧的生理、生化和形态学特征：半灌注犬实验模型的应用
Physiological, biochemical, and morphological characteristics of myocardial anoxia: the use of a semi-perfusion canine preparation.
作者信息
Bornet E P, Wood J M, Goldstein M A, Entman M L, Lewis R M, Dunn F A, Schwartz A
出版信息
Cardiovasc Res. 1977 Nov;11(6):568-75. doi: 10.1093/cvr/11.6.568.
PMID:603880
Abstract
Regional myocardial anoxia was produced in dogs by perfusion of the left circumflex artery (LCA) with deoxygenated blood. Isolated sarcoplasmic reticulum fragments (cardiac relaxing system) showed decreased Ca2+ binding and uptake. The ability of isolated mitochondria to utilise long-chain fatty acids was markedly reduced. This model has revealed inherent biochemical differences between ischaemia and anoxia.
摘要
通过向左回旋支动脉（LCA）灌注脱氧血液，在犬身上制造局部心肌缺氧。分离的肌浆网碎片（心脏舒张系统）显示钙离子结合和摄取减少。分离的线粒体利用长链脂肪酸的能力显著降低。该模型揭示了缺血和缺氧之间内在的生化差异。
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