热缺血后的肾功能。II. 在热缺血60、90和120分钟之前静脉注射肌苷的显著保护作用。

Renal function after warm ischaemia. II. Marked protective effect of intravenous inosine given prior to 60, 90 and 120 min of warm ischaemia.

作者信息

Fernando A R, Armstrong D M, Griffiths J R, Hendry W F, O'Donoghue E P, Watkinson L E, Whitfield H N, Wickham J E

出版信息

Eur Urol. 1977;3(6):355-8.

Abstract

Rats were given 10 or 20 mg of inosine dissolved in 1 ml of 0.9% saline, or a control solution of 1 ml of 0.9% saline, intravenously 10 or 20 min before induction of left renal warm ischemia for 60 min. Further groups of rats were treated with 20 mg inosine or with saline alone 20 min before longer periods of warm ischeamia of 90 and 120 min duration. All animals had immediate contralateral nephrectomy. In all inosine-treated groups the mean plasma creatinine was lower than in their respective control groups and these differences were statistically highly significant.

摘要

在诱导左肾热缺血60分钟前10或20分钟，给大鼠静脉注射溶解于1毫升0.9%盐水中的10毫克或20毫克肌苷，或1毫升0.9%盐水的对照溶液。另外几组大鼠在90分钟和120分钟更长时间的热缺血前20分钟，用20毫克肌苷或仅用盐水处理。所有动物均立即进行对侧肾切除术。在所有肌苷处理组中，平均血浆肌酐均低于各自的对照组，且这些差异具有高度统计学意义。