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流感病毒之间的RNA-RNA杂交

RNA-RNA hybridization between influenza viruses.

作者信息

Florent G

出版信息

Dev Biol Stand. 1977;39:11-14.

PMID:604092
Abstract

A study is described of the RNAs of recombinant viruses made from A/PR/8/34, which is non-infectious for man, and wild human Influenza A strains. By RNA-RNA hybridization it was possible to determine the proportion of the genome donated by each of the parents. The technique can be applied as a biochemical marker to detect the recombinants among parental viruses and moreover, it is a method to select the attenuated viruses among the recombinants.

摘要

一项关于由对人类无感染性的A/PR/8/34和野生人类甲型流感毒株构建的重组病毒RNA的研究。通过RNA-RNA杂交能够确定每个亲本提供的基因组比例。该技术可用作生化标记来检测亲本病毒中的重组体，此外，它还是一种在重组体中筛选减毒病毒的方法。

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