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小鼠中α-羟酸氧化酶和乙醇脱氢酶的遗传学：多个基因座的证据以及Hao-2和Adh-3之间的连锁关系。

The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3.

作者信息

Holmes R S

出版信息

Genetics. 1977 Dec;87(4):709-16. doi: 10.1093/genetics/87.4.709.

DOI:10.1093/genetics/87.4.709
PMID:604164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213772/
Abstract

Electrophoretic polymorphisms for stomach alcohol dehydrogenase (ADH-C2) and kidney L-alpha-hydroxyacid oxidase (HAOX-B4) have been identified in an Asian subspecies of mouse, Musmusculus castaneous. These variants are inherited in a normal Mendelian fashion with two alleles in each case showing codominant expression. The structural gene loci for those enzymes (Adh-3 and Hao-2, respectively) are apparently linked (17.6% recombinants) in this organism, whereas the multiple gene loci for HAOX, Hao-1 (encoding the A4 liver isozyme) and Hao-2, exhibited independent segregation and are unlinked (50% recombinants). Evidence is presented for 3 ADH loci: ADH-1, encoding liver ADH-A2 which exhibits high activity with ethanol (SELANDER, HUNT and YANG 1969; ADH-2, liver and stomach ADH-B2 using 2-hexene-1-ol as substrate; and Adh-3, stomach ADH-C2 using both benzyl alcohol and 2-hexene-1-ol as substrate.

摘要

在小家鼠亚洲亚种（M. castaneous）中已鉴定出胃醇脱氢酶（ADH-C2）和肾L-α-羟基酸氧化酶（HAOX-B4）的电泳多态性。这些变体以正常孟德尔方式遗传，每种情况下的两个等位基因均表现为共显性表达。在该生物体中，这些酶的结构基因座（分别为Adh-3和Hao-2）显然是连锁的（重组率为17.6%），而HAOX的多个基因座，即Hao-1（编码A4肝脏同工酶）和Hao-2，表现出独立分离且不连锁（重组率为50%）。文中提供了3个ADH基因座的证据：ADH-1，编码肝脏ADH-A2，对乙醇具有高活性（SELANDER、HUNT和YANG，1969年）；ADH-2，肝脏和胃中的ADH-B2，以2-己烯-1-醇为底物；以及Adh-3，胃中的ADH-C2，以苯甲醇和2-己烯-1-醇为底物。

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本文引用的文献

1
L-alpha-Hydroxy acid oxidases of hog renal cortex.猪肾皮质的L-α-羟酸氧化酶
J Biol Chem. 1962 Jun;237:2001-10.
2
Subunit composition of horse liver alcohol dehydrogenase.马肝醇脱氢酶的亚基组成。
Arch Biochem Biophys. 1969 Apr;131(1):288-98. doi: 10.1016/0003-9861(69)90133-7.
3
Purification and characterization of glycolic acid oxidase from pig liver.猪肝乙醇酸氧化酶的纯化与特性研究
Biochim Biophys Acta. 1971 Mar 10;227(3):500-20. doi: 10.1016/0005-2744(71)90003-9.
4
Structural and functional zinc in horse liver alcohol dehydrogenase.马肝醇脱氢酶中的结构锌和功能锌
Proc Natl Acad Sci U S A. 1967 May;57(5):1434-40. doi: 10.1073/pnas.57.5.1434.
5
The self-association of L-alpha hydroxyacid oxidase.
Biochim Biophys Acta. 1976 Apr 14;427(2):679-87. doi: 10.1016/0005-2795(76)90211-7.
6
Characterization of a nonhepatic alcohol dehydrogenase from rat hepatocellular carcinoma and stomach.
Arch Biochem Biophys. 1975 Nov;171(1):348-60. doi: 10.1016/0003-9861(75)90042-9.

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