小鼠中的α-羟酸氧化酶遗传学：肝脏同工酶存在两个基因位点及四聚体亚基结构的证据。
Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme.
作者信息
Duley J, Holmes R S
出版信息
Genetics. 1974 Jan;76(1):93-7. doi: 10.1093/genetics/76.1.93.
Abstract
We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C x NZC F(1) hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure.
摘要
我们研究了小家鼠近交系中肝脏GOX的多态性。遗传学研究表明，BALB/C和NZC亲本品系中该酶的两种表型的分离方式，就好像它们是由位于常染色体上一个单一基因座（GOX）的共显性等位基因所控制，该基因座与第五连锁群中的刺鼠基因座紧密连锁。在这些近交系中，肾脏HAOX活性不变，且由一个单独的基因座HAOX编码。BALB/C×NZC F(1)杂种小鼠除了具有亲本酶之外，还表现出三种肝脏GOX活性的中间形式，这与四聚体亚基结构一致。
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