Ewens W J, Thomson G
Genetics. 1977 Dec;87(4):807-19. doi: 10.1093/genetics/87.4.807.
The classical mathematical theory of population genetics considered, for simplicity, almost exclusively one-locus systems. In the last two decades much work has been done on two-locus and, less frequently, multi-locus systems. This research has usually involved investigating properties of systems with given, and usually rather special, fitness parameters. Real genetic fitness systems are undoubtedly multi-locus and seldom will possess simplifying characteristics. One aim of this paper is to study generalized systems where no special assumptions are made about fitness structure, the number of alleles at each locus, the number of loci involved or the recombination structure between loci. A second aim is to consider marginal properties (often one-locus properties) of complex systems: the fact that many observations involve data from only on locus makes this second aim relevant.
经典的群体遗传学数学理论为简化起见,几乎只考虑单基因座系统。在过去二十年里,针对双基因座系统开展了大量研究,而针对多基因座系统的研究则相对较少。这项研究通常涉及调查具有给定且通常相当特殊的适合度参数的系统的性质。实际的基因适合度系统无疑是多基因座的,而且很少会具有简化特征。本文的一个目的是研究广义系统,在该系统中,对于适合度结构、每个基因座的等位基因数量、所涉及的基因座数量或基因座之间的重组结构不做任何特殊假设。第二个目的是考虑复杂系统的边际性质(通常是单基因座性质):许多观测仅涉及来自一个基因座的数据这一事实使得第二个目的具有相关性。