Takehisa F, Kimura S
J Nutr Sci Vitaminol (Tokyo). 1977;23(5):431-7. doi: 10.3177/jnsv.23.431.
A study on how EFA deficiency affects lipid metabolism of rat skin, especially lipid on skin surface, was made. The total amount of lipid on skin surface of rat increased due to EFA deficiency, but not significantly. The sterol ester in skin surface lipid was maintained at a normal level in a EFA deficient rat, but the free sterol level was higher than that of the control rat. The glycerides decreased markedly due to EFA deficiency. It was recognized that branched fatty acids increased in each lipid fraction on skin surface. It was considered that such changes in skin surface lipid were characteristic to skin. It was not predictable whether these changes resulted directly from EFA deficiency or secondary from the occurrence of dermal symptoms.
开展了一项关于必需脂肪酸（EFA）缺乏如何影响大鼠皮肤脂质代谢，尤其是皮肤表面脂质代谢的研究。由于EFA缺乏，大鼠皮肤表面的脂质总量增加，但不显著。EFA缺乏的大鼠皮肤表面脂质中的甾醇酯维持在正常水平，但游离甾醇水平高于对照大鼠。甘油酯因EFA缺乏而显著减少。据认识，皮肤表面各脂质组分中的支链脂肪酸增加。据认为，皮肤表面脂质的这种变化是皮肤所特有的。无法预测这些变化是直接由EFA缺乏导致的，还是由皮肤症状的出现继发而来的。
