肠二肽水解部位。
Site of intestinal dipeptide hydrolysis.
作者信息
Wiseman G
出版信息
J Physiol. 1977 Dec;273(3):731-43. doi: 10.1113/jphysiol.1977.sp012120.
Abstract
- Sacs of everted small intestine of the hamster have been used to study the site of final hydrolysis of twelve dipeptides. 2. The results suggest that L-alanyl-glycine, glycyl-glycine, L-valyl-L-valine, L-alanyl-L-valine, L-valyl-L-alanine and L-prolyl-glycine are hydrolysed beyond the locus of the active transport mechanism for D-glucose, perhaps even within the cell. These may be designated class 1 (deep) dipeptides. 3. In contrast, superficial (perhaps even surface) hydrolysis seems to occur with L-alanyl-L-alanine, L-leucly-L-leucine, glycyl-L-alanine, L-alanyl-L-leucine, L-leucyl-L-alanine and glycyl-L-proline. These may be designated class 2 (superficial) dipeptides. 4. All the dipeptides were able to partially inhibit D-glucose active transport, the findings supporting the view that more than one mechanism may exist for the active absorption of the sugar.
摘要
- 仓鼠外翻小肠囊已被用于研究12种二肽的最终水解部位。2. 结果表明，L-丙氨酰甘氨酸、甘氨酰甘氨酸、L-缬氨酰-L-缬氨酸、L-丙氨酰-L-缬氨酸、L-缬氨酰-L-丙氨酸和L-脯氨酰甘氨酸在D-葡萄糖主动转运机制位点之外被水解，甚至可能在细胞内被水解。这些可被指定为1类（深度）二肽。3. 相比之下，L-丙氨酰-L-丙氨酸、L-亮氨酰-L-亮氨酸、甘氨酰-L-丙氨酸、L-丙氨酰-L-亮氨酸、L-亮氨酰-L-丙氨酸和甘氨酰-L-脯氨酸似乎发生表面（甚至可能是在表面）水解。这些可被指定为2类（表面）二肽。4. 所有二肽都能够部分抑制D-葡萄糖的主动转运，这些发现支持了这样一种观点，即糖的主动吸收可能存在不止一种机制。
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本文引用的文献
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