[鸟类肠道中的肽相互作用]

[Peptide interactions in the intestines of birds].

作者信息

Kushak R I, Basova N A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1983 Dec;69(12):1608-13.

Abstract

Interaction among various dipeptides was studied during their uptake in the mucosa of the small intestine of chicks. The effects observed were either inhibiting (L-valyl-L-valine inhibited the uptake of glycyl-L-alpha-alanine, glycyl-L-proline, L-leucyl-glycine, glycylglycine, and L-alpha-alanyl-L-alpha-alanine inhibited the uptake of glycyl-L-proline and L-leucylglycine) or stimulating (L-valyl-L-valine activated the uptake of glycyl-L-leucine), or neutral (L-alpha-alanyl-L-alpha-alanine exerted no significant effect on the absorption of glycyl-L-leucine and glycyl-L-valine). The amount and direction of the modifying effect depended on the agent concentration. Effects observed during the interaction of dipeptides and mixtures of free amino acids equimolar to them were identical. It is only possible if hydrolytic processes precede the transport and are closely related to them.

摘要

研究了雏鸡小肠黏膜摄取各种二肽过程中的相互作用。观察到的效应有抑制作用（L-缬氨酰-L-缬氨酸抑制甘氨酰-L-α-丙氨酸、甘氨酰-L-脯氨酸、L-亮氨酰-甘氨酸、甘氨酰甘氨酸的摄取，L-α-丙氨酰-L-α-丙氨酸抑制甘氨酰-L-脯氨酸和L-亮氨酰甘氨酸的摄取）、刺激作用（L-缬氨酰-L-缬氨酸激活甘氨酰-L-亮氨酸的摄取）或中性作用（L-α-丙氨酰-L-α-丙氨酸对甘氨酰-L-亮氨酸和甘氨酰-L-缬氨酸的吸收无显著影响）。修饰作用的大小和方向取决于试剂浓度。在二肽与等摩尔游离氨基酸混合物相互作用过程中观察到的效应是相同的。只有在水解过程先于转运且与转运密切相关时才有可能出现这种情况。