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The conversion of noncarcinogenic aromatic amides to carcinogenic arylhydroxamic acids by synthetic N-hydroxylation.

作者信息

Gutmann H R, Galitski S B, Foley W A

出版信息

Cancer Res. 1967 Aug;27(8):1443-55.

PMID:6047873
Abstract
摘要

相似文献

1
The conversion of noncarcinogenic aromatic amides to carcinogenic arylhydroxamic acids by synthetic N-hydroxylation.通过合成N-羟基化将非致癌性芳香酰胺转化为致癌性芳基异羟肟酸。
Cancer Res. 1967 Aug;27(8):1443-55.
2
The carcinogenicity of the o-methoxy derivatives of N-2-fluorenylacetamide and of related compounds in the rat.N-2-芴基乙酰胺的邻甲氧基衍生物及相关化合物对大鼠的致癌性。
Cancer Res. 1968 Feb;28(2):234-44.
3
On the correlation between the hepatocarcinogenicity of the carcinogen, N-2-fluorenylacetamide, and its metabolic activation by the rat.关于致癌物N-2-芴基乙酰胺的肝癌致癌性与其在大鼠体内的代谢活化之间的相关性
Cancer Res. 1972 Jul;32(7):1554-61.
4
Structure-activity relationships of N-acylarylhydroxylamines in the rat.大鼠体内N-酰基芳基羟胺的构效关系
Cancer Res. 1970 May;30(5):1485-98.
5
Mammary carcinogenesis in the rat by topical application of fluorenylhydroxamic acids.通过局部应用芴基异羟肟酸诱导大鼠乳腺癌发生
Cancer Res. 1973 Oct;33(10):2489-97.
6
The carcinogenicity of fluorenylhydroxamic acids and N-acetoxy-N-fluorenylacetamides for the rat as related to the reactivity of the esters toward nucleophiles.芴基异羟肟酸和N-乙酰氧基-N-芴基乙酰胺对大鼠的致癌性与酯对亲核试剂的反应活性的关系。
Cancer Res. 1975 Feb;35(2):447-59.
7
Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.羟胺和异羟肟酸的生化形成以及药理学、毒理学和病理学特性。
Pharmacol Rev. 1973 Mar;25(1):1-66.
8
Nucleophilic substitution on carcinogenic N-acetoxy-N-arylacetamides.
Cancer Res. 1970 Jun;30(6):1570-9.
9
Physiologic disposition of short chain aliphatic hydroxamates in the mouse. I. The one-through-four carbon hydroxamates: excretion and conversion to amides.
J Pharmacol Exp Ther. 1970 Aug;174(2):239-46.
10
N-hydroxy-2-fluorenylbenzamide, an arylhydroxamic acid with high carcinogenic activity.N-羟基-2-芴基苯甲酰胺，一种具有高致癌活性的芳基异羟肟酸。
Nature. 1966 Jan 8;209(5019):202-3. doi: 10.1038/209202b0.

引用本文的文献

1
N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems.N-乙酰-2-氨基芴（AAF）在原代培养的成年大鼠肝细胞中的代谢途径为高亲和力低速度和低亲和力高速度 AAF 代谢产物形成系统。
Toxicol Sci. 2018 May 1;163(1):26-34. doi: 10.1093/toxsci/kfy006.
2
N-Hydroxy-N-arylacetamides. I. Toxicity of certain polycyclic and monocyclic N-hydroxy-N-arylacetamides in rats.
Arch Toxicol. 1984 Dec;56(2):96-105. doi: 10.1007/BF00349079.
3
Pathobiologic and metabolic aspects of mammary gland tumorigenesis by N-substituted aryl compounds.N-取代芳基化合物诱发乳腺肿瘤发生的病理生物学和代谢方面
Environ Health Perspect. 1983 Mar;49:175-83. doi: 10.1289/ehp.8349175.
4
Carcinogenic action of 4-acetamidostilbene and the N-hydroxy derivative in the rat.4-乙酰氨基芪及其N-羟基衍生物在大鼠体内的致癌作用。
Br J Cancer. 1968 Mar;22(1):133-44. doi: 10.1038/bjc.1968.19.
5
The metabolism of 4-acetamidostilbene and its N-hydroxy derivative.4-乙酰氨基芪及其N-羟基衍生物的代谢
Br J Cancer. 1969 Sep;23(3):536-46. doi: 10.1038/bjc.1969.66.
6
[The genetic effect of aromatic amines and their derivatives: induction of mytotic conversion in the yeast Saccharomyces cerevisiae].
Z Krebsforsch. 1970;74(4):412-33.
7
Association of salmonella mutants with germfree rats: site specific model to detect carcinogens as mutagens.沙门氏菌突变体与无菌大鼠的关联：检测作为诱变剂的致癌物的位点特异性模型。
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4607-11. doi: 10.1073/pnas.72.11.4607.
8
Studies on the transformation of rat embryo cells of low passage by carcinogenic fluorenylhydroxamic acids and their acetate esters.致癌性芴基异羟肟酸及其乙酸酯对低代大鼠胚胎细胞转化的研究。
In Vitro. 1978 Mar;14(3):261-70. doi: 10.1007/BF02616035.