甲胎蛋白在先天性肾病综合征产前诊断中的应用

Alpha fetoprotein in the antenatal diagnosis of the congenital nephrotic syndrome.

作者信息

Wiggelinkhuizen J, Nelson M M, Berger G M, Kaschula R O

出版信息

J Pediatr. 1976 Sep;89(3):452-5. doi: 10.1016/s0022-3476(76)80549-5.

Abstract

In the congenital nephrotic syndrome (Finnish type), concentrations of alpha fetoprotein in the amniotic fluid and maternal serum are markedly elevated in the second trimester of pregancncy. Demonstration of this alteration allows early prenatal diagnosis of this fatal condition and elective termination of the pregnancy before 20 week's gestation.

摘要

在先天性肾病综合征（芬兰型）中，妊娠中期羊水和母血中甲胎蛋白的浓度会显著升高。这一变化的证实有助于对这种致命疾病进行早期产前诊断，并在妊娠20周前选择性终止妊娠。